R. Liu

Plasticity in nonsense-mediated decay and translation initiation regulate polyphenism

The paper investigates natural variation in mouth-form plasticity in Pristionchus pacificus, linking it to genetic and molecular mechanisms involving nonsense-mediated decay and alternative start codon selection.

Deciphering Ibogaines Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses

This study investigates how ibogaine and its metabolite noribogaine modulate monoamine transporters, revealing their unique pharmacological profile and explaining their therapeutic effects.

Comprehensive Biosynthetic Analysis of Human Microbiome Reveals Diverse Protective Ribosomal Peptides

This study identifies diverse ribosomally synthesized peptides in the human microbiome and shows some inhibit pathogens and reduce inflammation.

Temporal-spatially metabolic reprogramming rewires the H3K27ac landscape to enable the initiation of liver regeneration

This study identifies metabolic reprogramming and its impact on the H3K27ac epigenetic landscape during liver regeneration.

Durable Antimicrobial Microstructure Surface (DAMS) Enabled by 3D-Printing and ZnO Nanoflowers

This study develops a durable antimicrobial surface (DAMS) using 3D-printed microstructures and ZnO nanoflowers, showing over 90% bacterial reduction after 12 hours and effectiveness after abrasion.

Increased pathogenicity and transmission of SARS-CoV-2 Omicron XBB.1.9 sublineage, including HK.3 and EG.5.1

This study investigates the virological features of SARS-CoV-2 Omicron XBB.1.9 subvariants, finding increased pathogenicity and transmissibility in HK.3 and EG.5.1 compared to previous variants.

Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

This study shows that zebrafish gut microbiome influences protein absorption by altering lysosome-rich enterocytes' expression of digestion machinery and microbial interactions.

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses

The paper evaluates immunomodulatory drug responses in patient-derived tumor explant models of breast and renal cancer, finding reproducible gene expression and cytokine changes across models.

An AI-designed adenine base editor

This paper introduces ABE10, the first AI-designed adenine base editor validated experimentally, showing improved efficiency and reduced off-target effects compared to existing ABEs.

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturation

The paper uses flexible electronics to study electrical maturation of human pancreatic islets over time, identifying key electrical states and their role in hormone secretion.

Mycobacterium dormancy and antibiotic tolerance within the retinal pigment epithelium of ocular tuberculosis

This study investigates the metabolic mechanisms enabling Mycobacterium tuberculosis dormancy in retinal pigment epithelium cells and proposes a therapeutic strategy using phosphoenolpyruvate to enhance antibiotic efficacy.

The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells

This study shows PGE2 inhibits glucose-stimulated insulin secretion in β-cells via the EP2/4-Kv2.2 pathway by modulating Kv2.2 channels through PKA.

Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart? A crystallographic, biophysical, and theoretical study of the free enzyme and its complex with inhibitor 13b-K

This study investigates why the Omicron variant's main protease is less stable than the wild-type by analyzing its structure, enzymatic activity, and biophysical properties.

Within-host adaptation of a foliar pathogen, Xanthomonas, on pepper in presence of quantitative resistance and ozone stress

This study examines how elevated ozone stress affects the eco-evolutionary dynamics of Xanthomonas perforans on resistant and susceptible pepper cultivars, revealing increased disease severity and pathogen population heterogeneity.

Comparative transcriptome analysis provides insights into the resistance regulation mechanism and inhibitory effect of fungicide phenamacril in Fusarium asiaticum

This study identifies DEGs and their roles in phenamacril resistance in Fusarium asiaticum through comparative transcriptome analysis of sensitive and resistant strains.

Target-aware Molecule Generation for Drug Design Using a Chemical Language Model

This paper introduces TamGen, a chemical language model for target-aware molecule generation, and shows it produces high-quality compounds with inhibitory activity against Tuberculosis ClpP protease.

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

Berberine impairs spermatogenesis in mice by modulating ornithine metabolism via gut microbiota regulation

This study shows berberine reduces sperm count and testosterone in mice by altering gut microbiota, specifically reducing Muribaculaceae, and affecting ornithine metabolism.

Biosynthesis- and Metabolomics-guided discovery of antimicrobial cyclopeptides against drug-resistant clinical isolates

This study discovers new Avi(Me)Cys-containing cyclopeptide antibiotics effective against drug-resistant bacteria using genome mining and metabolomics.

Adaptation to volumetric compression drives hepatoblastoma cells to an apoptosis-resistant and invasive phenotype

This study shows that volumetric compression in liver cancer cells leads to transcriptional reprogramming, increased invasiveness, and chemoresistance, with potential reversal via calcium signaling.

A simple solid media assay for detection of synergy between bacteriophages and antibiotics

The paper develops a solid media assay to assess synergistic interactions between antibiotics and bacteriophages, identifying synergistic effects across diverse bacterial isolates.

Ser149 is another potential 14-3-3 epsilon binding site of Cdc25B in the G2/M transition of mouse fertilized eggs

This study identifies Ser149 as a 14-3-3 epsilon binding site on Cdc25B, showing its role in regulating G2/M transition in mouse fertilized eggs through phosphorylation and subcellular localization.

Patient-derived organoids assist personalized treatment for a patient with multiple metastatic neuroendocrine carcinoma of the cervix

The paper uses patient-derived organoids to model metastatic neuroendocrine carcinoma of the cervix and guide personalized treatment based on drug screening.

Physiological and metabolic insights into the first cultured anaerobic representative of deep-sea Planctomycetes bacteria

This study cultures a novel deep-sea Planctomycetes strain, characterizes its physiology and metabolism, and reveals nitrogen metabolism reprogramming by chronic bacteriophages.

Structure-Activity Relationship Study Identifies a Novel Lipophilic Amiloride Derivative that Efficiently Kills Chemoresistant Breast Cancer Cells

This study identifies a novel amiloride derivative, LLC1, that shows potent cytotoxicity against chemoresistant breast cancer cell lines but limited efficacy in a metastatic mouse model.

Respiratory Complex I Regulates Dendritic Cell Maturation in Explant Model of Human Tumor Immune Microenvironment

The paper uses a patient-derived explant model to show metformin enhances dendritic cell maturation by inhibiting complex I, improving anti-tumor immunity when combined with venetoclax.

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys

Single-cell RNA-sequencing identifies a novel subset of CD9+ reparative macrophages modulated by CCN2 derived from Nlrx1 deficient cardiomyocytes in the infarcted heart

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.