Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion
S. De Munter, J. Buhl, L. De Cock, A. Van Parys, W. Daneels, E. Pascal, L. Deseins, J. Ingels, G. Goetgeluk, L. Billiet, M. Pille, N. Vandamme, J. Van Dorpe, F. Offner, E. Depla, , B. Vandekerckhove
The paper shows that knocking out CD70 in CD70-specific nanoCAR T cells improves their functionality in vivo by preventing antigen-induced exhaustion.
bioRxiv · Jan 22, 2023Immunology