Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis
E. H. Puttock, E. J. Tyler, M. Manni, E. Maniati, C. Butterworth, E. Peerani, P. Hirani, V. Gauthier, Y. Liu, G. Maniscalco, V. Rajeeve, P. Cutillas, C. Trevisan, M. Pozzobon, M. Lockley, , O. M. T. Pearce
The paper shows that the tumor extracellular matrix educates macrophages to adopt a phenotype seen in ovarian cancer metastasis, affecting T cell function and immune regulation.
bioRxiv · Aug 11, 2022 · PreprintCancer Biology