A. White

Multispecies interactions and the community context of the evolution of virulence

The paper develops an eco-evolutionary model to show how host-host interactions influence pathogen virulence evolution, finding that competition increases virulence while mutualism decreases it.

Exploiting Bacterial Effector Proteins to Uncover Evolutionarily Conserved Antiviral Host Machinery

The paper identifies evolutionarily conserved host factors that restrict arbovirus replication by using bacterial effector proteins to rescue viral replication in insect cells.

Identification of CK2α' selective inhibitors by the screening of an allosteric-kinase-inhibitor-like compound library

The paper identifies two CK2α' selective inhibitors from a compound library using a kinase assay, offering potential for treating Huntington's disease.

Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium

The paper identifies a developmental pathway where CCL21-expressing thymic epithelial cells convert into self-antigen-displaying cells, contributing to functional diversity in the thymus medulla.

Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

The paper uses combined single-cell protein and RNA profiling to identify and characterize novel subpopulations of thymic epithelial cells and their functional roles.

Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis

The paper shows that the tumor extracellular matrix educates macrophages to adopt a phenotype seen in ovarian cancer metastasis, affecting T cell function and immune regulation.

Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis

The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.

Using NAMs to characterize chemical bioactivity at the transcriptomic, proteomic and phosphoproteomic levels

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

Induction of specific antibodies, IgG-secreting plasmablasts and memory B cells following BCG vaccination

This study investigates the BCG vaccine's induction of specific antibodies, IgG-secreting plasmablasts, and memory B cells in humans and macaques, highlighting the potential role of humoral immunity in TB vaccine development.

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

Role of substrate recognition in modulating strigolactone receptor selectivity in witchweed.

This study investigates how substrate recognition modulates strigolactone receptor selectivity in witchweed using molecular dynamics simulations and structural analysis.

Critical role of WNK1 in MYC-dependent early thymocyte development

This study identifies WNK1 as essential for thymocyte development by regulating ion homeostasis and MYC expression during the transition from double negative to double positive thymocytes.