CCM2 deficient endothelial cells undergo a mechano-dependent reprogramming into senescence associated secretory phenotype used to recruit endothelial and immune cells.
D. R. Vannier, A. Shapeti, F. Chuffart, E. Planus, S. Manet, P. Rivier, o. destaing, C. Albiges-Rizo, H. Van Oosterwyck, E. Faurobert
The paper shows that CCM2-deficient endothelial cells undergo mechano-dependent reprogramming into SASP, recruiting endothelial and immune cells.
bioRxiv · Feb 22, 2021Cell Biology