Trimethylamine N-Oxide (TMAO) links peripheral insulin resistance and cognitive deficiencies in a senescence accelerated mouse model
M. H. Janeiro, E. Puerta, M. Lanz, F. I. Milagro, M. J. Ramirez, M. Solas
This paper investigates the link between aging, insulin resistance, and cognitive decline in SAMP8 mice, finding that TMAO contributes to inflammation and cognitive deficits, which can be reversed by DMB treatment.
bioRxiv · Nov 17, 2021 · PreprintAnimal Behavior & Cognition