Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycobacterium tuberculosis
G. A. Harrison, K. Cho, E. R. Wang, S. Sarkar, F. Almqvist, G. Patti, C. L. Stallings
This paper identifies a compound, C10, that re-sensitizes drug-resistant Mycobacterium tuberculosis to isoniazid by exploiting a metabolic vulnerability, without altering InhA activity or INH-NAD levels.
bioRxiv · Feb 6, 2023 · PreprintMicrobiology