S. Sarkar

Graph-based modeling of multiparametric MRI deciphers molecular states of high-grade glioma invasion with prognostic implications

This paper uses graph-based modeling of multiparametric MRI to identify molecular states in high-grade glioma and shows their prognostic significance.

A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis

This paper introduces a fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis, demonstrating its utility in identifying EV proteins related to physical activity.

Conformational dynamics of electrostatically charged Intrinsically Disordered Proteins

The paper studies the conformational dynamics of highly charged intrinsically disordered proteins using a computational model and experimental measurements, finding slower loop-closing rates compared to uncharged IDPs.

A general approach to reduce off-target radioactivity in vivo via Tetrazine-Knock-Out (TKO)

This paper develops a method to rapidly clear radioactivity from blood using a tetrazine-knock-out (TKO) approach, improving imaging contrast and reducing radiation exposure.

G-Quadruplex Mediated c-myc Specific Downregulation: A Unique Pathway of the Anticancer Action of Immunomodulator Drugs

This study shows that HCQ and CQ downregulate c-myc oncogene transcription via G4 stabilization, reducing tumor growth and enhancing chemotherapy in breast cancer models.

Eubacterium rectale detoxification mechanism increases resilience of the gut environment

This study identifies Eubacterium rectale's detoxification mechanism, showing its ability to reduce ROS and inflammation in gut cells through glutathione production.

Microenvironment Drives Reentrant Condensation of Aβ40

This study computationally simulates how microenvironmental factors influence Aβ40's liquid-liquid phase separation, revealing salt-driven reentrant condensation and temperature-dependent behavior.

Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

This study develops a monoclonal antibody that broadly neutralizes multiple SARS-CoV-2 variants, including JN.1, and shows its protective efficacy in mice.

Autoaggregation in Streptococcus intermedius is driven by the Pel polysaccharide

This study identifies the Pel polysaccharide as a driver of autoaggregation in S. intermedius, linking it to biofilm formation and increased pathogenicity.

Two distinct integrin binding sites on MMP9 drive cancer invasion by mediating integrin membrane trafficking & stabilization

Intermolecular Energy Migration via HomoFRET Captures the Modulation in the Material Property of Phase-Separated Biomolecular Condensates

This study uses homoFRET to measure material property changes in biomolecular condensates, showing how factors like RNA and post-translational modifications affect their structure.

Reduction of chemokine CXCL9 expression by omega-3 fatty acids via ADP-ribosylhydrolase ARH3 in MIN6 insulin-producing cells

This study shows omega-3 fatty acids reduce CXCL9 expression in MIN6 cells via ARH3, potentially protecting beta cells from immune attack and preventing T1D.

Elucidating ATP's Role as Solubilizer of Biomolecular Aggregate

This study shows ATP prevents protein aggregation and dissolves pre-formed aggregates, suggesting it could be a therapeutic agent for protein-aggregation diseases.

Leveraging Soil Mapping and Machine Learning to Improve Spatial Adjustments in Plant Breeding Trials

The paper compares spatial adjustment methods in plant breeding trials, finding that XGBoost improves yield estimates by incorporating soil feature modeling at different scales.

Age-dependent Powassan Virus Lethality is Directed by Glial Cell Activation and Divergent Neuroinflammatory Cytokine Responses in a Murine Model

This study establishes a murine model of age-dependent Powassan virus (POWV) lethality, revealing divergent neuroinflammatory cytokine responses in young and old mice that correlate with CNS viral clearance and disease severity.

Multivalent DNA-encoded lectins on phage enable detecting compositional glycocalyx differences

This paper develops a phage-based liquid lectin array to detect subtle glycocalyx differences by displaying multivalent lectins on DNA-barcoded M13 phage.

Chandipura Virus forms cytoplasmic inclusion bodies through phase separation and proviral association of cellular protein Kinase R and stress granules protein TIA-1

This study shows Chandipura virus forms cytoplasmic inclusion bodies through phase separation involving PKR and TIA-1, evading antiviral stress granules and enhancing viral replication.

Spatially resolved single-cell analysis uncovers protein kinase C-& expressing microglia with anti-tumor activity in glioblastoma

This study identifies PKCδ-expressing microglia with anti-tumor activity in GBM using spatial transcriptomics and confirms their presence in human samples.

A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

This study identifies a mitochondrial quality control mechanism that reverses phagosome maturation arrest caused by Mycobacterium tuberculosis through RAB7 recruitment and lysosomal targeting.

Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice

This study shows that inhibiting PERK reduces autoimmune diabetes risk in mice by decreasing β cell immunogenicity and improving islet function.

Versatile Tissue-Injectable Hydrogels with Extended Hydrolytic Release of Bioactive Protein Therapeutics

This paper develops injectable hydrogels that enable controlled, extended release of protein therapeutics through hydrolysable linkers, demonstrating efficacy in a mouse melanoma model.

IFNγ modestly contributes to disease progression in the Ndufs4(-/-) model of Leigh syndrome while IP10 is dispensable

Tempered IL-2 Signals Program PD-1 Checkpoint Blockade-Responsive Stem-like Exhausted T Cells During Priming

This study shows that tempered IL-2 signals promote the development of PD-1 checkpoint blockade-responsive stem-like exhausted CD8 T cells during priming, while strong IL-2 signals drive terminal differentiation.

Single-Molecule FRET Illuminates Structural Subpopulations and Dissects Crucial Molecular Events During Phase Separation of a Prion-Like Low Complexity Domain

The paper uses single-molecule techniques to study phase separation of a prion-like domain, revealing structural subpopulations and molecular events involved in condensate formation and disease-related aggregation.

PLGA-based dual-loaded nanoformulation of DIM and TMZ - An advanced clinical strategy for brain cancer treatment in a combinatorial approach

This study develops a PLGA-based nanoformulation combining TMZ and DIM to enhance GBM treatment by improving drug delivery and synergistic cytotoxic effects.

Migration coupled with recombination explains disparate HIV-1 anatomical compartmentalization signals

This paper develops an evolutionary model incorporating migration and recombination to explain varying HIV-1 compartmentalization signals across tissues.

Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

This study uses Drosophila to investigate polyphosphate (polyP) functions, revealing its role in hemolymph clotting and developmental timing, with implications for mammalian systems.

Structural Basis of HIV-1 Maturation Inhibitor Binding and Activity

This study determines the structural basis of HIV-1 maturation inhibitor binding and resistance using NMR, revealing an allosteric mechanism and conformational changes in SP1 variants.

Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycobacterium tuberculosis

This paper identifies a compound, C10, that re-sensitizes drug-resistant Mycobacterium tuberculosis to isoniazid by exploiting a metabolic vulnerability, without altering InhA activity or INH-NAD levels.

Peripheral macrophages causally contribute to disease onset and progression in the Ndufs4(KO) model of Leigh syndrome

This study shows that peripheral macrophages contribute to CNS lesions in the Ndufs4(-/-) Leigh syndrome model, despite microglia depletion having limited effect.