K. Cho

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication

This study shows that pre-existing lung inflammation reduces SARS-CoV-2 replication by activating innate immune pathways, highlighting the role of the inflammatory microenvironment in controlling viral infection.

Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma

This study shows that TMZ efficacy in glioblastoma varies with time-of-day due to circadian rhythms in MGMT expression and promoter methylation, with optimal treatment at the peak of Bmal1 expression.

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-mediated gluconeogenesis in mice

This study investigates how liver mitochondrial pyruvate carrier deficiency affects de novo lipogenesis and glycerol-mediated gluconeogenesis in mice, finding impaired DNL but no reduction in intrahepatic lipid and unchanged glucose levels despite reduced glycerol metabolism.

Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycobacterium tuberculosis

This paper identifies a compound, C10, that re-sensitizes drug-resistant Mycobacterium tuberculosis to isoniazid by exploiting a metabolic vulnerability, without altering InhA activity or INH-NAD levels.

Mitochondrial Pyruvate Carrier Inhibition Initiates Metabolic Crosstalk to Stimulate Branched Chain Amino Acid Catabolism

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.

Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment

The paper identifies sex differences in glutamine metabolism in glioblastomas, showing male tumors have higher glutamine uptake and are more sensitive to GLS1 inhibition than female tumors.

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

This study identifies 535 novel genetic loci associated with blood pressure traits in over one million individuals of European ancestry.