Neo-functionalization in Saccharomyces cerevisiae: A Novel Nrg1-Rtg3 chimeric transcriptional modulator is essential to maintain mitochondrial DNA integrity
C. Campero-Basaldua, J. Gonzalez, J. Garcia-Rodriguez, E. Ramirez, H. Hernandez, B. Aguirre, N. Torres-Ramirez, D. Marquez, N. S. Sanchez, N. Gomez-Hernandez, L. Riego-Ruiz, C. Scazzocchio, A. Gonzalez
The paper identifies a chimeric Nrg1/Rtg3 regulator in yeast that is essential for maintaining mitochondrial DNA integrity, showing that its absence leads to irreversible mitochondrial DNA damage.
bioRxiv · May 17, 2023 · PreprintMicrobiology