A. Gonzalez

Intracellular lipopolysaccharide binds RETREG1/FAM134B to regulate ER remodeling upon bacterial infection

This study shows that bacterial LPS binds RETREG1 to induce ER remodeling and enhance antibacterial defense through ERphagy.

Gut microbiome is associated with recurrence-free survival in patients with resected Stage IIIB-D or Stage IV melanoma treated with immune checkpoint inhibitors

The paper identifies gut microbiome taxonomic markers associated with recurrence in melanoma patients treated with immune checkpoint inhibitors, showing generalizability across regions when GMB composition is matched.

Population estimates of shorebirds on the Atlantic Coast of southern South America generated from large-scale, simultaneous, volunteer-led surveys

The paper estimates shorebird populations along the Atlantic Coast of southern South America using volunteer-led surveys and remote sensing, finding high densities in wetlands and population declines for Nearctic species.

Rapid evaluation of habitat connectivity change to safeguard multispecies persistence in human-transformed landscapes

The paper evaluates habitat connectivity change from 2011 to 2021 in the St-Lawrence Lowlands for seven species, finding a decline in effective connected area and metapopulation carrying capacity despite stable total habitat area.

A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors

The paper identifies attractors in gene expression space for normal, Glioblastoma, and Alzheimer's disease in white matter and explores their relationships and implications for aging and disease.

Metapopulations, the inflationary effect, and consequences for public health

The paper examines the inflationary effect in metapopulations, showing how spatiotemporal heterogeneity enhances population stability and abundance, with implications for disease spread and public health.

Cross-species transmission and PB2 mammalian adaptations of highly pathogenic avian influenza A/H5N1 viruses in Chile

The paper tracks the emergence and mammalian adaptation of H5N1 HPAIV in Chile, identifying key mutations in the PB2 gene associated with cross-species transmission.

Macrophages sense ECM mechanics and growth factor availability through cytoskeletal remodeling to regulate their tissue repair program

Serine ubiquitination of p62 regulates Nrf2 dependent redox homeostasis

This study shows that serine ubiquitination of p62 by Legionella pneumophila SidE effectors inhibits Nrf2 signaling, altering redox homeostasis and host metabolism during infection.

Neo-functionalization in Saccharomyces cerevisiae: A Novel Nrg1-Rtg3 chimeric transcriptional modulator is essential to maintain mitochondrial DNA integrity

The paper identifies a chimeric Nrg1/Rtg3 regulator in yeast that is essential for maintaining mitochondrial DNA integrity, showing that its absence leads to irreversible mitochondrial DNA damage.

A synthetic delivery vector for mucosal vaccination

This paper develops a synthetic delivery vector for mucosal vaccination that induces mucosal immunity and CD8+ T cell responses in mice.

Amorphous calcium phosphate-coated surfaces as a model for bone microenvironment in prostate cancer

The paper develops a cost-effective method to coat cell culture vessels with amorphous calcium phosphate to model the bone microenvironment and shows its effect on prostate cancer cell survival.

Ecosystem connectivity and configuration can mediate instability at a distance in metaecosystems

The paper examines how ecosystem connectivity and configuration affect instability in metaecosystems, finding that trophic connectivity reduces instability compared to nutrient-only connectivity.

Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

Reconceptualizing beta diversity: a hypervolume geometric approach

This paper introduces a geometric hypervolume approach to measure beta diversity, accounting for non-additivity and species interactions, and applies it to address ecological questions.

Perfect genetic biomarkers for cancer from a fresh view of gene dysregulation

The paper identifies perfect gene panels for twelve solid tumors using formal concept analysis and rough set theory, achieving 100% sensitivity and specificity in distinguishing tumor and normal samples.

Rapid monitoring for ecological persistence

The paper shows that persistence of small ecological subnetworks can reliably predict the persistence of entire ecological networks, aiding conservation efforts.

Volumetric bioluminescence imaging of cellular dynamics with deep learning based light-field reconstruction

This paper improves bioluminescence microscopy with deep learning for low-light imaging, enabling high-resolution volumetric and timelapse imaging of cellular dynamics in living organisms.

Fish microbiomes 101: disentangling the rules governing marine fish mucosal microbiomes across 101 species

The paper analyzes microbiomes of 101 marine fish species to identify factors influencing microbial diversity and distribution across body sites and environments.

Bacterial metatranscriptomes in wastewater can differentiate virally infected human populations

The paper shows that bacterial metatranscriptomes in wastewater can distinguish SARS-CoV-2 infected from uninfected human populations without directly detecting viral transcripts.

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

A glyphosate-based herbicide cross-selects for antibiotic resistance genes in bacterioplankton communities

This study shows that glyphosate-based herbicides increase antibiotic resistance gene frequencies in freshwater bacterioplankton by selecting for multidrug efflux pumps.

Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE

The paper shows Sonic hedgehog (Shh) is sorted from the TGN to the basolateral surface and transcytosed to the apical domain via Rab11-ARE, involving Disp-1 and lipid modifications.

Missing interactions: the current state of multispecies connectivity analysis

The paper reviews multispecies connectivity analysis methods from 2010-2020, highlighting challenges in integrating species interactions and lacking standardized metrics for comparison.

Safety and efficacy of a new vaginal gel, Feminilove, for the treatment of symptoms associated with vaginal dryness and vulvovaginal atrophy in women: an in vitro and in vivo study

Multi-omics profiling of Earth's biomes reveals patterns of diversity and co-occurrence in microbial and metabolite composition across environments

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

Probiotic bacteria and bile acid profile are modulated by prebiotic diet and associate with facilitated diurnal clock/sleep realignment after chronic disruption of rhythms

This study shows that a prebiotic diet increases beneficial gut bacteria and bile acids, helping rats realign sleep and circadian rhythms after chronic disruption.

Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis

This paper shows that anakinra, an IL-1 receptor antagonist, reduces fat browning and muscle wasting in Ctns-/- mice, suggesting it could treat cachexia in infantile nephropathic cystinosis.

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

This study shows that blocking IL-1 receptor reduces adipose browning and muscle wasting in CKD-associated cachexia in mice.

VTAM: A robust pipeline for validating metabarcoding data using internal controls

VTAM validates metabarcoding data using internal controls, reducing false positives compared to DADA2 by addressing tag-jump and cross-sample contamination.