Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples
D. Saarela, P. Lis, S. Gomes, R. S. Nirujogi, W. Dong, E. Rawat, S. Glendinning, K. Zeneviciute, E. Bagnoli, R. Fasimoye, C. Lin, K. Nyame, F. A. Boros, F. Zunke, F. Lamoliatte, , E. Sammler
The paper develops a tagless LysoIP method to isolate lysosomes from clinical samples and human cell lines, revealing glycerophosphodiesters as potential biomarkers for lysosomal storage disorders.
bioRxiv · May 17, 2024Cell Biology