Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19
L. Thurner, N. Fadle, M. Bewarder, I. Kos, E. Regitz, O. Cetin, B. Thurner, Y. Fischer, T. Rixecker, K.-D. Preuss, C. Schormann, F. Neumann, S. Hartmann, T. Bock, D. Kaddu-Mulindwa, , S. Koerper
This study identifies autoantibodies against PGRN and IL-1-Ra in critical COVID-19 patients, linked to hyperphosphorylated isoforms and increased inflammation.
bioRxiv · Apr 23, 2021 · PreprintImmunology