S. Hartmann

Concurrent Ascaris infection modulates host immunity resulting in impaired control of Salmonella infection in pigs

This study shows that Ascaris infection in pigs impairs immune control of Salmonella, leading to higher bacterial burdens and increased susceptibility to coinfection.

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.

Population dynamics of free-roaming dogs in Europe and implications for population control

This study quantifies free-roaming dog population dynamics in Europe, finding lower survival and higher entry rates in Lviv compared to Pescara, and highlights the role of movement between subpopulations in recruitment.

Structure and Protein-Protein Interactions of Ice Nucleation Proteins Drive Their Activity

The paper determines the structure and protein-protein interactions of ice nucleation proteins and shows they are essential for their activity.

Assessing the impact of free-roaming dog population management through systems modelling

This study uses a systems model to evaluate dog population management strategies, finding that combining fertility control with responsible ownership interventions is most effective for long-term population reduction and welfare improvement.

A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae

This paper develops a synthetic glycoconjugate vaccine that combines pneumococcal proteins with a defined oligosaccharide to provide broad protection against multiple serotypes of Streptococcus pneumoniae in animal models.

Public attitudes towards free-roaming dogs and dog ownership practices in Bulgaria, Italy, and Ukraine

This study examines public attitudes and dog ownership practices in Bulgaria, Italy, and Ukraine to inform effective dog population management strategies.

Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19

This study identifies autoantibodies against PGRN and IL-1-Ra in critical COVID-19 patients, linked to hyperphosphorylated isoforms and increased inflammation.

A genomic assessment of the marine-speciation paradox within the toothed whale superfamily Delphinoidea

This study investigates post-divergence gene flow in Delphinoidea toothed whales using phylogenomics, allele distribution, and demographic analysis, revealing complex speciation involving ancient gene flow and limited contemporary hybridization.

Radula diversification promotes ecomorph divergence in an adaptive radiation of freshwater snails

The paper investigates the molecular basis of radula diversification in Tylomelania snails and finds stronger divergence in gene expression and coding sequences in radula transcriptomes compared to other tissues.

CD4+ Th immunogenicity of the Ascaris spp. secreted products

The paper identifies a human haplotype-specific T cell epitope in Ascaris suum secreted products using an in vitro antigen processing system and quantitative proteomics.

A helminth chitinase structurally similar to mammalian chitinase displays immunomodulatory properties

This paper identifies a helminth chitinase with immunomodulatory effects in a murine allergic model, showing structural similarity to mammalian chitinase and inducing cross-reactive antibodies.

A novel non-invasive method to detect gut barrier related changes during a gastrointestinal nematode infection.

This paper develops a non-invasive method to detect gut barrier changes during gastrointestinal nematode infection by measuring RELM-β expression in exfoliated epithelial cells from feces.

Population and conservation genomics of the world's rarest hyena species, the brown hyena (Parahyena brunnea)

This study analyzes the population and conservation genomics of the brown hyena, revealing low genetic diversity and potential sub-populations, with implications for its conservation.