Loss of the first β-strand of human prion protein generates an aggregation-competent partially "open" form
L. L. P. Hosszu, D. Sangar, M. Batchelor, E. Risse, A. M. Hounslow, J. P. Waltho, J. Collinge, J. Bieschke
This study examines the structural and functional changes in a truncated form of human prion protein lacking a conserved membrane region, showing it forms fibrils more readily than the native form.
bioRxiv · Sep 20, 2022 · PreprintBiophysics