Author

J. P. Waltho

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Biophysics· 1

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Approach:biophysical modeling· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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A. M. Hounslow· 1 shared D. Sangar· 1 shared E. Risse· 1 shared J. Bieschke· 1 shared J. Collinge· 1 shared L. L. P. Hosszu· 1 shared M. Batchelor· 1 shared

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2022-2022 · peak 1/yr

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1 shared paperBiophysics

A. M. Hounslow

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintSep 20, 2022

Loss of the first β-strand of human prion protein generates an aggregation-competent partially "open" form

L. L. P. Hosszu, D. Sangar, M. Batchelor…·J. Bieschke

This study examines the structural and functional changes in a truncated form of human prion protein lacking a conserved membrane region, showing it forms fibrils more readily than the native form.

DOI 10.1101/2022.09.20.508729

humanprotein structure

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