The Autophagy Receptor TAX1BP1 (T6BP) is a novel player in antigen presentation by MHC-II molecules.
M. Pereira, C. Richetta, G. Sarango, A. Kumari, M. Ghosh, L. Bertrand, C. Pionneau, M. Le Gall, S. Gregoire, R. Jeger-Madiot, E. Rosoy, F. Subra, O. Delelis, M. Faure, A. Esclatine, , A. Moris
This study identifies T6BP as a critical regulator of endogenous MHC-II antigen presentation by affecting peptide loading and CD74 stability.
bioRxiv · Apr 21, 2021 · PreprintImmunology