L. Bertrand

Metformin protects the heart against chronic intermittent hypoxia through AMPK-dependent phosphorylation of HIF-1α

This study shows metformin protects the heart from chronic intermittent hypoxia by activating AMPK2, which phosphorylates and inhibits HIF-1α, reducing mitochondrial damage.

A NRF2/beta3-adrenoreceptor axis drives a sustained antioxidant and metabolic rewiring through the pentose-phosphate pathway to alleviate cardiac stress

This study identifies a NRF2/beta3-adrenoreceptor axis that enhances antioxidant defenses and metabolic rewiring via the pentose-phosphate pathway, protecting cardiac function under stress.

Sodium-myo-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice

This study shows that SMIT1 promotes cardiac hypertrophy and fibrosis in mice under pressure overload by enhancing IP3/Ca2+-dependent signaling pathways.

Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals

The paper characterizes HIV-1 translational landscape, revealing uORF translation and its role in DDX3 dependency and T cell immune responses.

The Autophagy Receptor TAX1BP1 (T6BP) is a novel player in antigen presentation by MHC-II molecules.

This study identifies T6BP as a critical regulator of endogenous MHC-II antigen presentation by affecting peptide loading and CD74 stability.

Restore mitophagy is essential to prevent cardiac oxidative stress during hypertrophy

This study investigates the role of mitochondrial oxidative stress in cardiac hypertrophy and evaluates the effects of two antioxidants, MitoQ and EUK 134, on cardiomyocyte function and hypertrophy.

Beta-3 Adrenoreceptors protect from hypertrophic remodelling through AMP-Activated Protein Kinase and Autophagy.

This study shows that beta3-adrenergic receptors reduce cardiac hypertrophy by activating AMPK and preserving autophagy in both in vitro and in vivo models.

Different salicylic and jasmonic acids imbalances are involved in the oxidative stress-mediated cell death, induced by fumonisin B1 in maize seedlings with contrasting resistance to Fusarium verticillioides ear rot in the field.

This study investigates how fumonisin B1 induces oxidative stress and cell death in maize seedlings with different resistance to Fusarium ear rot, revealing distinct salicylic and jasmonic acid imbalances.