M. Ghosh

The Implant-Induced Foreign Body Response is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins

This study shows CD13 regulates macrophage fusion by controlling ubiquitination of fusogenic proteins, limiting foreign body response fibrosis and suggesting CD13 as a therapeutic target.

An explainable machine learning data analytics method using TIGIT-linked genes for identifying biomarker signatures to clinical outcomes.

The paper develops an explainable machine learning model using TIGIT-linked genes to predict survival outcomes in breast cancer patients.

SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss

This study shows that loss of chromosome 18q in human embryonic stem cells impairs neuroectoderm commitment and cardiac progenitor differentiation through SALL3 downregulation.

Immunogenicity of non-canonical HLA-tumor ligands identified through proteogenomics

The paper investigates the immunogenicity of non-canonical HLA-I ligands from tumor cells and finds they are not recognized by autologous T-cells but can be targeted by donor T-cells, suggesting potential as immunotherapy targets.

The DEAD-box protein p68 and B-catenin: the crucial regulators of FOXM1 gene expression in arbitrating colorectal cancer

This study identifies p68 and β-catenin as regulators of FOXM1 gene expression, showing their role in colorectal cancer progression through promoter activity and oncogenic functions.

Harmonin homology domain-mediated interaction of RTEL1 helicase with RPA and DNA provides mechanistic insight into its role in DNA repair

This study identifies a novel interaction between RTEL1 and RPA, showing their co-localization during DNA damage and revealing structural details of HHD2 binding to RPA and DNA.

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma

Losartan prevents ICB-induced cerebral edema and improves survival in glioblastoma mice, with a predictive immune signature identified.

p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression

This study shows p53 suppresses tumors by promoting TREX1 degradation, leading to cytosolic DNA accumulation and activation of the cGAS/STING pathway, which induces type I interferons.

The Autophagy Receptor TAX1BP1 (T6BP) is a novel player in antigen presentation by MHC-II molecules.

This study identifies T6BP as a critical regulator of endogenous MHC-II antigen presentation by affecting peptide loading and CD74 stability.

REPEATED INJURY PROMOTES TRACHEOBRONCHIAL TISSUE STEM CELL ATTRITION

This study shows repeated injury depletes tracheobronchial tissue stem cells, leading to abnormal repair and chronic lung disease.

Differential host response to a herpesvirus: Mareks disease virus peptides on chicken MHC class II molecules are derived from only a few genes and illustrate a new mode of peptide binding

The paper identifies that Mareks disease virus peptides presented by chicken MHC class II molecules come from only four genes, revealing a new peptide binding mode and explaining MHC-driven resistance to the virus.

Proteoglycan 4 (PRG4) expression and functionin dry eye associated inflammation

This study examines PRG4 expression and function in dry eye disease, showing its anti-inflammatory effects and role in ocular surface homeostasis.

Machine Learning-Based Protein Microarray Digital Assay Analysis

The paper develops a microfluidic digital immunoassay using machine learning for rapid, multiplexed biomarker detection in clinical samples.

An innovative approach for HLA typing, molecular tumor testing and the validation of tumor exclusive antigens

The paper describes an innovative approach for HLA typing, molecular tumor testing, and validation of tumor-exclusive antigens but has been withdrawn by the authors.

CD13 is a Critical Regulator of Cell-cell Fusion in Osteoclastogenesis

This study shows CD13 regulates cell-cell fusion in osteoclastogenesis and multinucleated giant cell formation, independent of RANKL signaling.

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

This study identifies mtp53's role in suppressing innate immune signaling by inhibiting TBK1, promoting tumorigenesis through immune evasion.

Antigens in water-in-oil emulsion: a simple antigen extraction method for analysis and proof of equal antigen distribution in vaccination syringe after mixture

The paper develops a simple method to extract and analyze peptides from a water-in-oil emulsion to verify equal distribution in a vaccination syringe.

Validation of a high-performance liquid chromatography-tandem mass spectrometry immunopeptidomics assay for the identification of HLA class I ligands suitable for pharmaceutical therapies

The paper validates an LC-MS/MS immunopeptidomics assay for identifying HLA class I ligands suitable for personalized immunotherapy.

Splicing inhibition enhances the antitumor immune response through increased tumor antigen presentation and altered MHC-I immunopeptidome

This study shows that splicing inhibition with IP2 enhances antitumor immunity by increasing antigen presentation and altering MHC-I immunopeptidomes.