5,6-dimethylxanthenone-4-acetic acid (DMXAA), a Partial STING Agonist, Competes for Human STING Activation
B. Temizoz, T. Shibahara, K. Hioki, T. Hayashi, K. Kobiyama, M. S. J. Lee, N. Surucu, E. Sag, A. Kumanogoh, M. Yamamoto, M. Gursel, S. Ozen, E. Kuroda, C. Coban, K. J. Ishii
This paper investigates DMXAA's partial STING agonist activity and develops HHMX, a derivative that antagonizes STING-mediated immune responses in both humans and mice.
bioRxiv · Dec 7, 2023 · PreprintImmunology