Dual Palmitoylation of PRCD, a Photoreceptor-Specific Protein Linked to RP, Alters Protein Stability and Subcellular Localization
B. O. R. Myers, E. Sechrest, G. Hamner, S. Motipally, J. Murphy, S. Kolandaivelu
This study shows PRCD is dually palmitoylated at two sites, with mutations affecting protein stability and trafficking to photoreceptor outer segments, contributing to retinitis pigmentosa.
bioRxiv · May 30, 2022 · PreprintBiochemistry