J. Murphy

Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain

This paper develops and validates new tools for multi-organ neuroimaging of neural and vascular dynamics in the brain and spinal cord, including 3D-printed implants and bioluminescent imaging.

Surveillance of Vermont wildlife in 2021-2022 reveals no detected SARS-CoV-2 viral RNA

The study tested 739 Vermont wildlife samples for SARS-CoV-2 and found no viral RNA, contrasting with findings in other North American deer populations.

Dual Palmitoylation of PRCD, a Photoreceptor-Specific Protein Linked to RP, Alters Protein Stability and Subcellular Localization

This study shows PRCD is dually palmitoylated at two sites, with mutations affecting protein stability and trafficking to photoreceptor outer segments, contributing to retinitis pigmentosa.

Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer

The paper identifies three subtypes of MMR deficient colorectal cancer based on genetic and immune landscape evolution, linking them to T-cell infiltrates and checkpoint-inhibitor resistance.

The central nucleus of the amygdala and gustatory cortex assess affective valence during CTA learning and expression in male and female rats

This study examines how male and female rats assess the affective valence of a stimulus during CTA learning and expression, revealing sex-specific neural and behavioral responses.

Motor unit recruitment patterns of the quadriceps differ between continuous high- and low-torque isometric knee extension to momentary failure

This study compares motor unit recruitment patterns during high- and low-torque isometric knee extensions to momentary failure using sEMG frequency analysis, finding similar overall recruitment but differing temporal patterns.

Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8

The paper identifies a novel interaction between BRD8 and the NuA4 complex using chemoproteomics and develops selective probes for BRD8.

Miniaturized Devices for Bioluminescence Imaging in Freely Behaving Animals

This paper demonstrates a modified fluorescent miniscope capable of detecting bioluminescence in vivo with improved sensitivity and reduced hardware complexity.

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

Polyphosphate initiates tau aggregation through intra- and intermolecular scaffolding

This study shows polyphosphate initiates tau aggregation by altering its conformation and enabling noncovalent cross-linking.

HIV population-level adaptation can rapidly diminish the impact of a partially effective vaccine

This study shows that HIV can adapt rapidly to partially effective vaccines, reducing their impact and increasing new infections in vaccinated populations.