A distinct signalling circuit upregulates cytotoxic ROS production in a cellular model of Parkinsons disease: key roles for TRPM2, Zn2+ and complex III
M. AlAhmad, H. Isbea, E. Shitaw, F. Li, A. Sivaprasadarao
The paper identifies a novel signalling circuit involving TRPM2, NOX2, Ca2+, Zn2+, and complex III that drives cytotoxic ROS production in Parkinson's disease.
bioRxiv · Jan 8, 2024 · PreprintCell Biology