F. Li

Interpretable Aging Signatures in Human Retinal Cell Types Revealed by Single-Cell RNA Sequencing and Sparse Logistic Regression

The paper identifies cell-type-specific aging signatures in human retinal cells using single-cell RNA sequencing and machine learning, revealing molecular changes and vulnerabilities associated with aging.

The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly

The paper presents structures of AFPKs from Elysia chlorotica, revealing the ACP linker's role in regulating substrate and product selectivity during polyketide and fatty acid synthesis.

Temporal-spatially metabolic reprogramming rewires the H3K27ac landscape to enable the initiation of liver regeneration

This study identifies metabolic reprogramming and its impact on the H3K27ac epigenetic landscape during liver regeneration.

Microbial single-cell omics in situ

The paper reports a method using LIFT technology to obtain high-quality microbial single-cell genomes or transcriptomes from complex samples and demonstrates its application to study cell-fate commitment in sporulation.

Antimicrobial Profile from Frog Skin Peptides

This study evaluates the antimicrobial efficacy of frog skin peptides against bacteria and fungi, finding Magainin 2 and Bombesin effective against Bacillus subtilis, Escherichia coli, and Trichoderma harzianum.

Positionally distinct interferon stimulated dermal immune acting fibroblasts promote neutrophil recruitment in Sweet's syndrome

This study identifies interferon-responsive dermal fibroblasts in Sweet's syndrome that promote neutrophil recruitment through chemokine expression and spatial positioning.

The effects of L-carnitine and fructose in improved Ham's F10 on sperm culture in idiopathic severe asthenospermia within 24h

This study evaluates the effects of L-carnitine and fructose in modified Ham's F10 medium on sperm motility in idiopathic severe asthenospermia patients within 24h, finding improved viability at specific concentrations and temperature.

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.

Heparan sulfate regulates amphiregulin signaling towards reparative lung mesenchymal cells during influenza A infection

This study shows heparan sulfate is essential for Areg signaling in lung mesenchymal cells during influenza A infection, affecting reparative responses.

A conserved lysine/arginine-rich motif in potyviral 6K1 protein is key in engaging autophagy-mediated self-degradation for completing pepper veinal mottle virus infection

This study identifies a conserved lysine/arginine-rich motif in potyviral 6K1 protein that mediates autophagy-mediated self-degradation, essential for viral infection.

Caspase-8-mediated CYLD cleavage boots LPS-induced endotoxic shock.

This study identifies Caspase-8-mediated CYLD cleavage as a mechanism promoting LPS-induced endotoxic shock and reveals CP25 as a potential biomarker.

Multi-compartment impact of micropollutants and particularly antibiotics on bacterial communities using environmental DNA at river basin-level

This study evaluates how micropollutants, especially antibiotics, affect bacterial communities in different environmental compartments of a river basin, showing reduced diversity and altered functional capabilities in polluted sites.

BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer

This study shows BET inhibition in liver cancer reduces proliferation by inducing GDH1-dependent glutamine metabolic changes, suggesting a therapeutic strategy combining BET and OXPHOS inhibitors.

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

CMTM6 maintains B cell intrinsic CD40 expression to regulate anti-tumor immunity

This study shows that CMTM6 in B cells maintains CD40 membrane levels by inhibiting its degradation, which is essential for B cell activation, anti-tumor immunity, and the effectiveness of CD40 agonists and ICB therapy.

A resource to enable chemical biology and drug discovery of WDR Proteins

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

The paper introduces MEMORY, a method to identify GEARs associated with cancer prognosis, finding mitosis-related genes in LUAD and immunity-related genes in BRCA.

A distinct signalling circuit upregulates cytotoxic ROS production in a cellular model of Parkinsons disease: key roles for TRPM2, Zn2+ and complex III

The paper identifies a novel signalling circuit involving TRPM2, NOX2, Ca2+, Zn2+, and complex III that drives cytotoxic ROS production in Parkinson's disease.

Targeting transcription factors through an IMiD independent zinc finger domain

This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation.

This study shows that LIPUS reduces microglial activation and improves tissue-microelectrode integration after intracortical implantation.

VHL loss enables immune checkpoint blockade therapy by boosting type I interferon response.

This study shows that VHL loss in ccRCC enhances anti-PD-1 therapy efficacy by increasing type I interferon response through HIF1/HIF2-mediated mtDNA leakage.

CEP44 is required for maintaining centriole duplication and spindle integrity

This study identifies CEP44's role in preventing centriole overduplication and maintaining spindle integrity, linking it to breast carcinoma prognosis.

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase transition potential

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

Recruitment of FBXO22 for Targeted Degradation of NSD2

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

A dipteran parasite regulates 20E synthesis and antibacterial activity of the host for development through inducing host nitric oxide production

This study shows that a dipteran parasite increases host nitric oxide production to regulate 20E synthesis and antibacterial activity, supporting its development.

ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy

This study identifies ROCK1 activation as a driver of mitochondrial fission and oxidative stress in CKD-induced muscle wasting, showing pharmacological inhibition of ROCK1 can alleviate these effects.

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

This paper introduces a computational pipeline for identifying SARS-CoV-2 nsp14 inhibitors using virtual screening, identifying seven candidates including NSC620333 and SS148, with experimental validation of binding affinity and structural insights.

Membrane positioning across antigen-induced synaptic contacts tunes CAR-T cell signaling and effector responses

This study shows that varying CAR-antigen complex span affects CAR-T cell activation and effector responses, with optimal activation occurring at a span matching TCR-pMHC complexes.

A redundant chloroplast protein is co-opted by potyvirids as the scaffold protein to mediate viral intercellular movement complex assembly

This study identifies HCPro2 as a potyvirus-encoded scaffold protein that interacts with viral and host factors to assemble an intercellular movement complex, promoting viral infection.