Cell BiologybioRxivPreprint
Protein kinase Cϵ activation induces EHD-dependent degradation and downregulation of KATP channels: Implications for glucose stimulated insulin secretion
C. J. Cockcroft, P. Manna, R. Karnik…·A. Sivaprasadarao
This study shows that PKCε activates EHD-dependent lysosomal degradation of KATP channels, contributing to glucose-stimulated insulin secretion through ATP-independent mechanisms.
DOI 10.1101/2020.01.15.907386