The N-glycosylation defect in Lec5 and Lec9 CHO cells is caused by absence of the DHRSX gene
T. Kentache, C. R. Althoff, F. Caligiore, E. Souche, C. Schulz, J. Graff, E. Pieters, P. Stanley, J. Contessa, E. Van Schaftingen, G. Matthijs, F. Foulquier, G. T. Bommer, M. P. Wilson
This study identifies DHRSX gene absence as the cause of dolichol synthesis defect in Lec5 and Lec9 CHO cells, correcting N-glycosylation defects through DHRSX complementation.
bioRxiv · Jun 18, 2024 · PreprintBiochemistry