C. Schulz

The N-glycosylation defect in Lec5 and Lec9 CHO cells is caused by absence of the DHRSX gene

This study identifies DHRSX gene absence as the cause of dolichol synthesis defect in Lec5 and Lec9 CHO cells, correcting N-glycosylation defects through DHRSX complementation.

Innate immune memory after brain injury drives inflammatory cardiac dysfunction

This study identifies innate immune memory after brain injury as a driver of chronic cardiac dysfunction, showing that post-stroke epigenetic changes in myeloid cells lead to inflammation and fibrosis in the heart.

Increased pulmonary monocyte infiltration and attenuated phagocytosis defines perinatal dysfunction of innate immunity in Cystic Fibrosis

The paper identifies increased monocyte infiltration and reduced phagocytosis in CF lungs at birth, suggesting innate immune dysfunction and the need for early treatment.

Vaccination with Helicobacter pylori attachment proteins protects against gastric cancer

This study shows that vaccination with H. pylori attachment protein BabA induces blocking antibodies that reduce gastric inflammation and prevent gastric cancer in mice.

Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

This study shows resident macrophages improve cardiac remodelling while recruited macrophages influence infarct size after myocardial ischemia/reperfusion injury.

A critical role of retinoic acid concentration for the induction of a fully human-like atrial phenotype in hiPSC-CM

This study shows that 1 μM retinoic acid is necessary and sufficient to induce a fully human-like atrial phenotype in hiPSC-CMs, overcoming methodological challenges in RA concentration control.

The lncRNA landscape of cardiac resident macrophages and identification of Schlafenlnc as a regulator of macrophage migratory function

The paper identifies lncRNAs in cardiac resident macrophages and shows Schlafenlnc regulates macrophage migration.

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

Scent dog identification of SARS-CoV-2 infections, similar across different body fluids

Dogs trained to detect SARS-CoV-2 in inactivated saliva samples showed high sensitivity and specificity in identifying non-inactivated samples from saliva, urine, and sweat.

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

This study identifies an early interferon-stimulated gene (ISG) upregulation as a protective immune signature in non-pneumonic SARS-CoV-2 infection, preventing progression to pneumonia.

Integrated scRNA-seq analysis identifies conserved transcriptomic features of mononuclear phagocytes in mouse and human atherosclerosis

This study integrates scRNA-seq data from mouse and human atherosclerosis to identify conserved transcriptomic features of mononuclear phagocytes across species.

Multi-species ELISA for the detection of antibodies against SARS-CoV-2 in animals

The paper develops a multi-species ELISA to detect SARS-CoV-2 antibodies in animals, achieving 100% specificity and 98.31% sensitivity across multiple species.

Tertiary lymphoid tissue develops during normal aging in mice and humans

This study identifies bladder tertiary lymphoid tissue (bTLT) formation in aged mice and humans, driven by TNF and linked to age-related bladder inflammation.

TGF-βRII knock-down promotes tumor growth and chemoresistance to gemcitabine of pancreatic cancer cells via phosphorylation of STAT3