A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreas cancer
B. A. Brown, P. J. Myers, S. J. Adair, J. R. Pitarresi, S. K. Sah-Teli, L. A. Campbell, W. S. Hart, M. Barbeau, K. Leong, N. Seyler, W. Kane, K. E. Lee, E. Stelow, M. Jones, M. C. Simon, , M. J. Lazzara
This study identifies a hypoxia-driven histone methylation-MAPK feedback loop that sustains EMT in pancreatic cancer, with potential therapeutic implications.
bioRxiv · Oct 19, 2022 · PreprintCancer Biology