Author

K. E. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

A. Mello· 1 shared A. Rao· 1 shared B. A. Brown· 1 shared B. Z. Stanger· 1 shared C. Cai· 1 shared E. S. Carpenter· 1 shared E. Stelow· 1 shared H. C. Crawford· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Mello

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Non-physiologic interaction of MG53 with insulin receptor and lack of evidence for MG53's role in controlling insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues.

K. E. Lee, M. Nishi, J. Kim, T. Murayama, Z. Dawson, X. Wang, X. Zhou, T. Tan, C. Cai, H. Takeshima, K. H. Park

This study investigates whether MG53 interacts with the insulin receptor and affects Akt phosphorylation in muscle, heart, and liver tissues, finding low binding affinity and no effect on insulin signaling.

bioRxiv · Jan 26, 2024 · PreprintPhysiology

A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreas cancer

B. A. Brown, P. J. Myers, S. J. Adair, J. R. Pitarresi, S. K. Sah-Teli, L. A. Campbell, W. S. Hart, M. Barbeau, K. Leong, N. Seyler, W. Kane, K. E. Lee, E. Stelow, M. Jones, M. C. Simon, , M. J. Lazzara

This study identifies a hypoxia-driven histone methylation-MAPK feedback loop that sustains EMT in pancreatic cancer, with potential therapeutic implications.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

A. Mello, T. Ngodup, Y. Lee, K. L. Donahue, J. Li, A. Rao, E. S. Carpenter, H. C. Crawford, M. Pasca di Magliano, K. E. Lee

This study shows hypoxia drives an inflammatory phenotype in pancreatic cancer-associated fibroblasts, promoting tumor IL1 expression and iCAF formation in hypoxic regions.

bioRxiv · May 5, 2022Cancer Biology