Mitochondrial uncouplers impair human sperm motility without altering ATP content
W. M. Skinner, N. T. Petersen, B. Unger, S. Tang, E. Tabarsi, J. Lamm, L. Jalalian, J. Smith, A. M. Bertholet, K. Xu, Y. Kirichok, P. V. Lishko
This study shows mitochondrial uncouplers impair human sperm motility without reducing ATP content, suggesting ATP-independent mechanisms and potential contraceptive applications.
bioRxiv · Aug 4, 2022Cell Biology