J. Smith

Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes

This study shows that protein interactions, calcium, phosphorylation, and cholesterol regulate CFTR cluster formation on membranes through multivalent interactions and phase separation.

Sleep deprivation and the rodent psychomotor vigilance test (rPVT): Assessing lapses in attention, the response stimulus interval effect, and time on task in rats using food reinforcement

This study assesses the effects of sleep deprivation on rodent psychomotor vigilance test performance in food-restricted rats, finding increased lapses and slower reaction times.

Variability and correlations among vital rates and their influence on population growth in mule and black-tailed deer

This study identifies adult female survival as the key factor influencing population growth in mule and black-tailed deer, showing it explains 62% of variation in lambda, with populations declining when survival drops below 70%.

Evolutionary genomics reveals variation in structure and genetic content implicated in virulence and lifestyle in the genus Gaeumannomyces

This study generates high-quality genome assemblies for Gaeumannomyces species, revealing virulence lineage variation and genomic features linked to pathogenicity and lifestyle.

Intrauterine Growth-Restricted Pregnant Rats, from Hypertensive Placental Ischemic Dams Display Preeclamptic-like Symptoms: A New Rodent Model of Preeclampsia

This study establishes a new rodent model of preeclampsia by inducing intrauterine growth restriction in pregnant rats, showing elevated blood pressure and oxidative stress.

Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot

This paper shows that combining RASG12C(ON) and SHP2 inhibitors can make cold lung tumors responsive to immune checkpoint blockade by altering the tumor microenvironment and enhancing anti-tumor immunity.

Global spatial potential for implementing land-based climate mitigation

The paper estimates global land suitability for 19 land-based climate mitigation strategies, identifying areas of conflict and compatibility.

Giant genes are rare but implicated in cell wall degradation by predatory bacteria

The paper identifies giant genes in predatory bacteria, showing they are associated with prey adhesion and cell wall degradation.

Disulfiram reduces atherosclerosis and enhances efferocytosis, autophagy, and atheroprotective gut microbiota in hyperlipidemic mice.

Quantifying the linkages between California sea lion (Zalophus californianus) strandings and particulate domoic acid concentrations at piers across Southern California

The paper links California sea lion strandings to particulate domoic acid concentrations at piers, showing that higher concentrations predict increased strandings.

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

The paper identifies ABHD17B as a therapeutic target for liver fibrosis by showing its depletion inactivates hepatic stellate cells and reduces fibrosis in mice.

Estimating the reproduction number, R0, from agent-based models of tree disease spread

The paper estimates the basic reproduction number R0 for tree diseases using agent-based models and applies these methods to the ash dieback epidemic in the UK.

Mosquito midgut stem cell cellular defense response limits Plasmodium parasite infection

The paper investigates how mosquito midgut stem cells respond to Plasmodium infection by proliferating and enabling enteroblasts to eliminate parasites.

Unique interactions and functions of the mitochondrial small Tims in Trypanosoma brucei

This study identifies unique interactions and functional roles of small TbTims in the TbTIM17 complex of T. brucei, revealing distinct complex architectures and dynamics.

Highly pathogenic avian influenza causes mass mortality in Sandwich tern (Thalasseus sandvicensis) breeding colonies across northwestern Europe

This study reports mass mortality of Sandwich terns due to HPAI A(H5N1) in northwestern Europe, with over 17% of the breeding population dying and high chick mortality observed.

Rab46: a novel player in mast cell function

This study identifies Rab46 as a key regulator of stimulus-dependent degranulation in mast cells, showing its expression and functional impact in human and murine cells.

Evolution of promoter-proximal pausing enabled a new layer of transcription control

The paper investigates the evolutionary emergence of RNA polymerase II pausing and its regulatory role across species.

Glucocorticoid and adrenergic receptor distribution across human organs and tissues: a map for stress transduction

This study maps glucocorticoid and adrenergic receptor expression across human organs, showing tissue-specific patterns and their link to mitochondrial pathways in stress responses.

Miltefosine attenuates inflammation, reduces atherosclerosis, and alters gut microbiota in hyperlipidemic mice.

Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.

This study shows that GsdmD in myeloid cells promotes lung cancer metastasis in mice by enhancing inflammasome activity and IL-1β release.

Mitochondrial uncouplers impair human sperm motility without altering ATP content

This study shows mitochondrial uncouplers impair human sperm motility without reducing ATP content, suggesting ATP-independent mechanisms and potential contraceptive applications.

Structure-based identification of novel histone deacetylase 4 (HDAC4) inhibitors

The paper identifies novel HDAC4 inhibitors using molecular modeling and in vivo testing, finding compounds that selectively target HDAC4 over other HDAC classes.

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

This study shows that targeted degradation of PCNA via biodegraders leads to more effective anti-proliferative effects and programmed cell death compared to stoichiometric inhibition.

Location bias contributes to functionally selective responses of biased CXCR3 agonists

The paper shows that biased CXCR3 agonists produce different signaling outcomes based on subcellular location, with endosomal signaling playing a key role in biased activation.

Paracrine role for endothelial IGF-1 receptor in white adipocyte beiging

This study shows that reducing endothelial IGF-1R in nutrient excess promotes white adipocyte beiging, increases energy expenditure, and improves insulin sensitivity through paracrine malonic acid release.

Simultaneous in vivo Pharmacokinetics and Pharmacodynamics of TDF Intravaginal Ring during High-dose Vaginal SHIV Challenge in Pigtail Macaques

This study examines TFV distribution and protection efficacy of a TDF IVR in macaques during high-dose SIV challenge, finding uneven TFV distribution and incomplete protection.

Broadening a SARS-CoV-1 neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

This paper describes engineering a SARS-CoV-1 neutralizing antibody to effectively neutralize SARS-CoV-2 through directed evolution and affinity maturation.

Could radical pairs play a role in xenon-induced general anesthesia?

This study proposes that xenon-induced anesthesia may involve radical pair dynamics influenced by xenon's nuclear spin, showing isotopic dependence in mice.

Complex population dynamics in a spatial microbial ecosystem with Physarum polycephalum

This study examines the population dynamics between Physarum polycephalum and a red yeast in a spatial ecosystem, revealing an inverse growth relationship and oscillatory dynamics.