S. Tang

Unicellular cyanobacteria rely on sodium energetics to fix N2

This study shows that unicellular cyanobacteria rely on sodium energetics for N2 fixation, which may explain their low abundance in coastal waters due to insufficient NaCl levels.

Imaging and quantification of prostate cancer-associated bone by polarization-sensitive optical coherence tomography

This study uses PS-OCT to differentiate bone tissue types in prostate cancer metastases by analyzing collagen organization and quantifying structural features.

GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

Bet hedging in a unicellular microalga

The paper demonstrates bet hedging in the microalga Haematococcus pluvialis through reversible phenotypic diversification into mobile and non-mobile subunits, enhancing population persistence under environmental stress.

Label-Free Composition Analysis of Supramolecular Polymer - Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector

This paper develops a label-free RPLC-CAD method to analyze supramolecular hydrogel composition and drug payload, demonstrating its applicability for rheological and release kinetic studies.

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

This paper describes a ferritin-based nanoparticle vaccine, DCFHP-alum, that induces strong, long-lasting neutralizing antibodies against SARS-CoV-2 variants in non-human primates.

Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies

This study shows that stabilizing the HIV-1 gp41 hydrophobic pocket with a modified peptide improves antibody response and neutralizing activity against HIV-1.

Designing epitope-focused vaccines via antigen reorientation

This paper introduces an antigen reorientation strategy using oligoD insertion to shift immune responses toward conserved epitopes, demonstrating improved cross-reactivity in influenza vaccines.

An alternative malonyl-CoA producing pathway in nature

The paper identifies an alternative pathway for malonyl-CoA production using oxaloacetate dehydrogenase in Streptomyces, enabling efficient bioproduction of malonyl-CoA-derived chemicals in E. coli.

RyR2 regulates store-operated Ca2+ entry, phospholipase C activity, and electrical excitability in the insulinoma cell line INS-1

This study shows RyR2 regulates SOCE, PLC activity, and electrical excitability in INS-1 cells by modulating PIP2 levels and Cav channel currents.

Injectable polymer-nanoparticle hydrogel for the sustained intravitreal delivery of bimatoprost

This paper develops an injectable polymer-nanoparticle hydrogel for sustained intravitreal delivery of bimatoprost, showing prolonged drug release and minimal inflammation in rabbits.

Mitochondrial uncouplers impair human sperm motility without altering ATP content

This study shows mitochondrial uncouplers impair human sperm motility without reducing ATP content, suggesting ATP-independent mechanisms and potential contraceptive applications.

Rescue of alveolar wall liquid secretion blocks fatal lung injury by influenza-staphylococcal coinfection

This study shows that influenza virus inhibits alveolar wall liquid secretion, promoting fatal lung injury from staphylococcal infection, and that restoring this secretion protects against lung damage.

Regulation of protein translation by TRIM21

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

Subtyping evaluation of Salmonella Enteritidis using SNP and core genome MLST with nanopore reads

This study evaluates the use of nanopore sequencing for SNP and cgMLST subtyping of Salmonella Enteritidis, showing high concordance with Illumina data despite sequencing errors.

Phenotypic plasticity, life cycles and the evolutionary transition to multicellularity

The paper identifies an environmentally driven facultative multicellular life cycle in Cyanothece sp. ATCC 51142, showing that filament dissolution is triggered by environmental changes and modeled as a density-dependent sensing system.

Systematic analysis of the R2R3-MYB family of transcription factors in Camellia sinensis: evidence for species-specific catechin biosynthesis regulation

This study identifies R2R3-MYB transcription factors in C. sinensis and links some to the regulation of galloylated catechin biosynthesis.

SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc- SMPDL3B

This study identifies SIRT1's role in regulating sphingolipid metabolism and neural differentiation in mESCs via c-Myc and SMPDL3B, suggesting therapeutic potential for neurological diseases.

The role of AUX1 during lateral root development in the domestication of the model C4 grass Setaria italica

This study identifies SiAUX1 as critical for lateral root development in Setaria italica, revealing its role in cell volume distribution and vascular strand formation through mutant analysis and RNAseq.

Integrative Clinical and Molecular Characterization of Translocation Renal Cell Carcinoma

This study characterizes translocation renal cell carcinoma (tRCC) through integrated clinical and molecular analysis of 152 patients, identifying key features like MiT/TFE fusions, NRF2-driven antioxidant response, and differential treatment outcomes.

Deacetylation of IFIT2 mediated by HDAC5 promotes the stemness and progression of glioma

This study shows that HDAC5 deacetylates IFIT2, promoting glioma stemness and progression by inducing IFIT2 ubiquitination and loss of anti-tumor activity.

Ras guanine nucleotide exchange factor RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

Design Principles of the ESCRT-III Vps24-Vps2 Module

The paper identifies three minimal features required for ESCRT-III function through analysis of subunit interactions and mutations in yeast.

Evaluation of Nanopore sequencing technology to differentiate Salmonella serotypes and serotype variants with the same or closely related antigenic formulae

This study evaluates Nanopore sequencing for differentiating Salmonella serotypes and variants with similar antigenic formulas using SNP analysis and prophage prediction.

A single immunization with spike-functionalized ferritin vaccines elicits neutralizing antibody responses against SARS-CoV-2 in mice

This study shows that a single dose of spike-functionalized ferritin vaccines in mice generates neutralizing antibodies against SARS-CoV-2, with S{Delta}C-Fer showing higher efficacy than other spike formats.

Phenotype Spectrum reflects Synergies among the Cell Architecture over Stages of the Cell Cycle

The paper investigates the relationship between cell cycle phases and migratory behaviors in NIH 3T3 fibroblasts, showing synergies between cell cycle regulators and migration.

Integrative Molecular Characterization of Sarcomatoid and Rhabdoid Renal Cell Carcinoma Reveals Determinants of Poor Prognosis and Response to Immune Checkpoint Inhibitors

This study characterizes the molecular features and immune profile of sarcomatoid and rhabdoid renal cell carcinoma, showing their responsiveness to immune checkpoint inhibitors and identifying key genetic and transcriptional determinants.

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson's disease mouse brain

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections

This study shows that ANXA2 depletion increases CMHs in rickettsia and Ebola virus infections by disrupting BBB tight junctions.

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.