Persistent DNA damage promotes microglial dysfunction in Ataxia-telangiectasia
J. Bourseguin, W. Cheng, E. Talbot, L. Hardy, S. V. Khoronenkova
This study shows that DNA damage in Ataxia-telangiectasia leads to microglial dysfunction via the RELB/p52 pathway, causing excessive neurite phagocytosis and contributing to neurodegeneration.
bioRxiv · Jun 2, 2021Cell Biology