W. Cheng

High-Resolution Spatial Transcriptomic Atlas of Mouse Soleus Muscle: Unveiling Single Cell and Subcellular Heterogeneity in Health and Denervation

An integrated signaling threshold initiates IgG response towards virus-like immunogens

The paper identifies that a combination of surface antigen density and internal nucleic acids is sufficient to initiate strong antiviral IgG responses without T cell help or Toll-like receptor signaling.

Quantitative dynamics of intracellular NMN by genetically encoded biosensor

This study develops a genetically encoded biosensor to measure intracellular NMN dynamics in live cells and identifies Slc25a45 as a potential mitochondrial NMN transporter.

Multiscale effects of perturbed translation dynamics inform antimalarial design

The paper determines in situ structures of Pf80S ribosomes in Plasmodium falciparum-infected erythrocytes, identifies a bifurcation in translation elongation, and links perturbations to inhibitor effects on ribosome interactions.

Rapid and visual detection of Schistosoma japonicum circulating nucleic acids by CRISPR-Cas12a

This paper develops a CRISPR-Cas12a-based method for detecting Schistosoma japonicum circulating nucleic acids with high sensitivity and specificity, validated using rabbit serum samples.

Minimal determinants for lifelong antiviral antibody responses in BALB/c mice from a single exposure to virus-like immunogens at low doses

This study shows that a single low-dose injection of virus-like immunogens induces lifelong neutralizing antibodies in mice, highlighting key determinants for durable antiviral immunity.

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell Lines

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

This study identifies the molecular mechanisms by which particulate antigens induce potent B cell responses, showing signal amplification and reduced proliferation thresholds independent of T cell help and BCR avidity.

Quantitative proteomics combined with network pharmacology analysis unveils the biological basis of Schisandrin B in treating diabetic nephropathy

This study identifies the mechanisms of Schisandrin B in treating diabetic nephropathy using network pharmacology and quantitative proteomics in rats.

Predicting Pacific cod spawning habitat in a changing climate

This study predicts changes in suitable spawning habitat for Pacific cod under climate change using climate models and experimental data on temperature effects on hatch success.

The special and general mechanism of cyanobacterial harmful algal blooms

The paper examines the special and general mechanisms of cyanobacterial harmful algal blooms, identifying ecological and evolutionary factors that enable cyanobacteria to dominate under eutrophic conditions.

Persistent DNA damage promotes microglial dysfunction in Ataxia-telangiectasia

This study shows that DNA damage in Ataxia-telangiectasia leads to microglial dysfunction via the RELB/p52 pathway, causing excessive neurite phagocytosis and contributing to neurodegeneration.

Multi-omics consensus ensemble refines the classification of muscle-invasive bladder cancer with stratified prognosis, tumour microenvironment and distinct sensitivity to frontline therapies

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

Decoupling of rates of protein synthesis from cell expansion leads to supergrowth

The paper shows that fission yeast can accumulate biomass without expanding in volume, leading to supergrowth when volume expansion resumes.

HiAlc Klebsiella pneumonia, one of potential chief culprits of non-alcoholic fatty liver disease: through generation of endogenous ethanol

This study identifies HiAlc Klebsiella pneumoniae as a contributor to non-alcoholic fatty liver disease by inducing endogenous ethanol production in mice and humans.

Long noncoding RNA ANRIL supports proliferation of adult T-cell leukemia cells through cooperation with EZH2

This study identifies ANRIL as a key lncRNA promoting HTLV-1-induced ATL cell proliferation through interaction with EZH2 and activation of NF-κB.