Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression
H. E. V. Gamage, S. H. Shahoei, S. T. Albright, Y. Wang, A. J. Smith, R. Farmer, E. C. Fink, E. Jacquin, E. Weisser, R. O. Bautista, M. A. Henn, C. P. Schane, A. T. Nelczyk, L. Ma, A. Das Gupta, , E. R. Nelson
This paper shows that NR0B2 in myeloid cells reduces Treg expansion and tumor growth by modulating the NLRP3 inflammasome, with small molecule agonists improving ICB efficacy in breast cancer.
bioRxiv · Aug 14, 2023 · PreprintCancer Biology