Author

A. J. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 2 Biochemistry· 1 Pathology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. Zhang· 2 shared A. Caldwell· 1 shared A. Das Gupta· 1 shared A. K. Bartlett· 1 shared A. Leverett· 1 shared A. M. Borland· 1 shared A. R. Chevalier· 1 shared A. Rasmussen-Arda· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

J. Zhang

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC

X. Yuan, X. Hao, H. L. Chan, N. Zhao, D. A. Pedroza, F. Liu, K. Le, A. J. Smith, S. J. Calderon, N. Lieu, M. J. Soth, P. Jones, X. H.- F. Zhang, J. M. Rosen

CBP/P300 BRD inhibition reduces neutrophil accumulation and enhances antitumor immunity in neutrophil-enriched TNBC, improving responses to standard therapies.

bioRxiv · Apr 25, 2024 · PreprintCancer Biology

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

E. H. Rashan, A. K. Bartlett, D. B. Khana, J. Zhang, R. Jain, A. J. Smith, Z. N. Baker, T. Cook, A. Caldwell, A. R. Chevalier, B. F. Pfleger, P. Yuan, D. Amador-Noguez, J. A. Simcox, D. J. Pagliarini

This study identifies ACAD10 and ACAD11 as enzymes critical for metabolizing 4-hydroxy fatty acids in mammals, revealing their unique mechanisms and subcellular localization.

bioRxiv · Jan 9, 2024Biochemistry

Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression

H. E. V. Gamage, S. H. Shahoei, S. T. Albright, Y. Wang, A. J. Smith, R. Farmer, E. C. Fink, E. Jacquin, E. Weisser, R. O. Bautista, M. A. Henn, C. P. Schane, A. T. Nelczyk, L. Ma, A. Das Gupta, , E. R. Nelson

This paper shows that NR0B2 in myeloid cells reduces Treg expansion and tumor growth by modulating the NLRP3 inflammasome, with small molecule agonists improving ICB efficacy in breast cancer.

bioRxiv · Aug 14, 2023 · PreprintCancer Biology

Ship-to-Shore Training for Active Deep-Sea Capacity Development

K. A. Barnhill, B. Vinha, A. J. Smith, D. de Jonge, D. Y. Gaurisas, R. M. Segura, P. Madureira, M. Albuquerque, V. A. I. Huvenne, C. Orejas, V. Gunn

This study evaluates a telepresence-based training program for early career researchers in deep-sea science, finding it effective in providing inclusive and accessible remote participation.

bioRxiv · Mar 11, 2023Scientific Communication & Education

Cardiomyocyte alpha-1A adrenergic receptors mitigate post-infarct remodeling and mortality by constraining necroptosis

J. Zhang, P. B. Sandroni, W. Huang, L. Oswalt, A. J. Smith, T. Ash, S.-H. Lee, Y.-Y. I. Shih, H.-Y. S. Huang, B.-E. Myagmar, J. C. Schisler, B. C. Jensen

This study shows that cardiomyocyte alpha-1A adrenergic receptors reduce post-infarct mortality and remodeling by limiting necroptosis, with clinical evidence linking beta-blocker use to increased MI mortality.

bioRxiv · Aug 29, 2022 · PreprintPathology

Dissecting Succulence: Crassulacean Acid Metabolism and Hydraulic Capacitance are Independent Adaptations in Clusia Leaves

A. Leverett, S. Hartzell, K. Winter, M. Garcia, J. Aranda, A. Virgo, A. J. Smith, P. Focht, A. Rasmussen-Arda, W. G. T. Willats, D. Cowan-Turner, A. M. Borland

This study examines the relationship between succulence, CAM, and hydraulic capacitance in Clusia leaves, finding they are independent traits with distinct roles in drought tolerance.

bioRxiv · Mar 30, 2022Plant Biology

3D visualisation of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads

T. M. D. Sheard, M. E. Hurley, A. J. Smith, J. Colyer, E. White, I. Jayasinghe

This study uses 3D visualization to examine RyR cluster structure and JPH2 sub-domains in cardiac dyads, revealing fragmentation in disease states.

bioRxiv · Oct 21, 2021 · PreprintBiophysics

Imatinib mesylate induces necroptotic cell death and impairs autophagic flux in human cardiac progenitor cells

R. Walmsley, D. S. Steele, G. M. Ellison-Hughes, A. J. Smith

This study shows imatinib mesylate causes necroptotic cell death and impairs autophagy in human cardiac progenitor cells, with RIP1 inhibition reducing toxicity.

bioRxiv · Apr 12, 2021 · PreprintPharmacology & Toxicology

Controlling protein nanocage assembly with hydrostatic pressure

K. K. Le Vay, B. M. Carter, D. W. Watkins, T.-Y. D. Tang, V. P. Ting, H. Cölfen, R. P. Rambo, A. J. Smith, J. L. R. Anderson, A. W. Perriman

This study shows that hydrostatic pressure can reversibly dissociate E. coli bacterioferritin into dimers, with heme B stabilizing the cage structure.

bioRxiv · Jun 16, 2020 · PreprintBiophysics

An Exon Skipping Screen Identifies Antitumor Drugs That Are Potent Modulators of Pre-mRNA Splicing, Suggesting New Therapeutic Applications

Y. Shi, W. Bray, A. J. Smith, W. Zhou, J. Calaoagan, C. Lagisetti, L. Sambucetti, P. Crews, R. S. Lokey, T. R. Webb

The paper identifies antitumor drugs that modulate pre-mRNA splicing through a screening assay, revealing new therapeutic applications and SF3B1 antagonists.

bioRxiv · Mar 21, 2019Cancer Biology