ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism.
G. Dematteis, L. Tapella, C. Casali, M. Talmon, E. Tonelli, S. Reano, A. Ariotti, E. Pessolano, M. Malecka, G. Chrostek, G. Kilkoviene, D. Umbrasas, C. Distasi, M. Grilli, G. Ladds, , D. Lim
The paper shows that an optimal ER-mitochondria distance of ~20 nm is critical for efficient Ca2+ transfer and mitochondrial oxidative metabolism, with reduced distances observed in Parkinson's disease astrocytes.
bioRxiv · Jul 24, 2024Cell Biology