D. Lim

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism.

The paper shows that an optimal ER-mitochondria distance of ~20 nm is critical for efficient Ca2+ transfer and mitochondrial oxidative metabolism, with reduced distances observed in Parkinson's disease astrocytes.

Multiscale mechanisms driving tissue rupture by invading cells

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

A Parasite Odyssey: An RNA virus concealed in Toxoplasma gondii

The paper identifies a novel narnavirus, Apocryptovirus odysseus, potentially infecting Toxoplasma gondii, and suggests it may act as a pro-inflammatory factor in host cells.

A molecular glue approach to control the half-life of CRISPR-based technologies

This paper introduces a molecular glue approach using pomalidomide to control the half-life of CRISPR-based technologies, enabling precise regulation of their activity and therapeutic potential.

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

Label-free bone marrow white blood cell classification using refractive index tomograms and deep learning

This paper presents a label-free method for classifying bone marrow white blood cells using 3D refractive index tomograms and deep learning, achieving high accuracy in subtype classification.

Time-dynamics of mitochondrial membrane potential reveal an inhibition of ATP synthesis in mitosis

The paper quantifies mitochondrial ATP synthesis rates during mitosis and finds a 50% decrease in early mitosis linked to CDK1 activity.

Quality of eyeglass prescriptions from a low-cost wavefront autorefractor evaluated in rural India: results of a 708-participant field study

This study evaluates a low-cost wavefront autorefractor's ability to provide accurate eyeglass prescriptions in rural India, finding comparable visual acuity and patient preference to subjective refraction.