P. Ghosh

Drug resistance through ribosome splitting and rRNA disordering in mycobacteria

This study reveals how mycobacterial HflX mediates ribosome splitting and antibiotic resistance through rRNA disordering and anti-association mechanisms.

Molecular Signatures for Microbe-Associated Colorectal Cancers

The paper identifies a Microbe-Associated Colorectal Cancer Signature (MACS) induced by Fusobacterium nucleatum in genetically predisposed hosts, linking microbial infection to early CRC initiation.

Cell surface RNA expression modulates alveolar epithelial function

This study identifies glycoRNA as a novel component of the alveolar epithelial glycocalyx and shows its role in barrier regulation and viral infection.

A reaction-diffusion model captures the essence of liquid-liquid phase separation

This paper develops a reaction-diffusion model to simulate liquid-liquid phase separation, showing how diffusivity and interactions affect droplet formation and stability.

Conservation of C4BP-binding Sequence Patterns in Streptococcus pyogenes M and Enn Proteins

The paper identifies and refines C4BP-binding patterns in Streptococcus pyogenes M and Enn proteins, showing their conservation and utility for vaccine design.

Rapid differentiation of estrogen receptor status in patient biopsy breast cancer aspirates with an optical nanosensor

This paper develops an optical nanosensor using carbon nanotubes to rapidly detect estrogen receptor status in breast cancer biopsies with high accuracy.

Physics-informed machine learning for automatic model reduction in chemical reaction networks

This paper introduces a physics-informed machine learning framework for automatic model reduction in chemical reaction networks, enhancing efficiency and accuracy in simulating complex systems like Aβ fibril aggregation.

Structural Requirements for Reverse Transcription by a Diversity-generating Retroelement

This study identifies how surrounding RNA structures facilitate reverse transcription in DGRs by positioning an RNA homoduplex for cis-priming and regulating mutagenesis.

Hindlimb Unloading Induces Bone Microarchitectural and Transcriptomic Changes in Murine Long Bones in an Age-Dependent Manner

This study shows that hindlimb unloading causes age-dependent changes in bone microarchitecture and gene expression in mice, with younger mice showing senescence pathway activation and older mice showing mitochondrial dysfunction.

Machine Learning Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers

This paper introduces a machine learning framework to identify and target transcriptomic vulnerabilities in colorectal cancer, demonstrating that differentiation therapy selectively eliminates cancer stem cells and reduces recurrence risk.

Transcriptome profiling of type VI secretion system core gene tssM mutant of Xanthomonas perforans highlights regulators controlling diverse functions ranging from virulence to metabolism

This study profiles the transcriptome of a T6SS core gene mutant in Xanthomonas perforans to identify regulators affecting virulence, metabolism, and other functions.

Spatiotemporal dynamics and emergent ordering in a mixture of morphologically distinct bacteria having different cell motility

This study uses agent-based modeling to show how morphology and motility differences between bacterial species affect their spatial organization and collective behavior in mixed populations.

Assessment of Nutrient Composition and utilization of some popular wild Edible fruits of Kumaun Himalayan Region as Anti-oxidant agents

This study evaluates the nutrient composition and antioxidant potential of six wild edible fruits from the Kumaun Himalayan region, identifying Diospyros kaki and Rubus niveus as promising sources of antioxidants and micronutrients.

Diverse Gut Pathogens Exploit the Host Engulfment Pathway via a Conserved Mechanism

The paper identifies a conserved molecular interface between WxxxE-effector proteins from gut pathogens and the host protein ELMO1, showing how pathogens exploit the host's engulfment pathway.

A Multiomic Analysis Reveals How Breast Cancers Disseminated to the Bone Marrow Acquire Aggressive Phenotypes through Tumor-Stroma Tunnels

This study identifies GIV as a key protein transferred from mesenchymal stromal cells to ER+ breast cancer cells via tunnelling nanotubes, driving aggressive tumor phenotypes.

Hierarchy and networks in the transcriptional response of Mycobacterium abscessus to antibiotics

This study identifies WhiB7-dependent and -independent pathways in M. abscessus antibiotic resistance, revealing gene regulators and resistance mechanisms.

A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics

This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.

Intracellular interaction of FNDC1/FN1/AR/cMYC in prostate cancer cells

The paper investigates the interaction of FNDC1/FN1/AR/cMYC in prostate cancer cells and finds they physically interact, with FN1/AR/cMYC also interacting in normal cells.

Growth Signaling Autonomy in Circulating Tumor Cells Aids Metastatic Seeding

This study defines the transcriptome, proteome, and phenome of growth signaling autonomy in breast cancer cells and shows its role in metastatic progression and drug resistance.

Phosphorylation of Gαi shapes canonical Gα(i)βγ/GPCR signaling

This study identifies phosphorylation sites on Gαi that modulate GPCR signaling by altering Gi activation and localization, revealing mechanisms of cross-talk between growth factor and chemokine signaling pathways.

Water-Quality analysis and Fish diversity of Southern West Part of the West-Bengal

The paper analyzes water quality and fish diversity along the East Medinipur coast in West Bengal, finding correlations between water parameters and species richness across seasons.

Strengthening of enterococcal biofilms by Esp

This study investigates the role of Esp in strengthening enterococcal biofilms under acidic conditions, showing that Esp unfolding and aggregation enhance biofilm stability.

A mechanistic understanding of biofilm morphogenesis: Coexistence of mobile and sessile aggregates and phase-separated patterns

This study develops a biophysical model to understand how bacterial microcolony morphology is shaped by EPS production and mechanical interactions, showing phase-separated patterns and coexistence of motile and sessile aggregates.

Coupling of NOD2 to GIV is Required for Bacterial Sensing

This paper identifies GIV as a NOD2-interactor that enhances bacterial sensing and signaling in macrophages, revealing how loss of function in the NOD2 1007fs variant impairs protective immune responses.

Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruption

This study shows that GM1-enriched liposomes promote toxic Aβ oligomerization and membrane disruption through cooperative processes.

AI-assisted Discovery of an Ethnicity-influenced Driver of Cell Transformation in Esophageal and Gastroesophageal Junction Adenocarcinomas

The paper uses AI to identify a racially influenced immune driver of esophageal and gastroesophageal junction adenocarcinomas, showing its absence in African Americans and association with neutrophil processes and genetic variants.

An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37

The paper reveals how M87 protein from Streptococcus pyogenes interacts with LL-37 by unfolding its coiled coil to expose a hydrophobic core, neutralizing the antimicrobial peptide.

Capturing a crucial 'disorder-to-order transition' at the heart of the coronavirus molecular pathology - triggered by highly persistent, interchangeable salt-bridges

The paper investigates the disorder-to-order transition in the SARS-CoV-2 Spike protein upon Furin binding, highlighting salt-bridge networks and their role in proteolytic cleavage efficiency.

Design of a Streptococcus pyogenes M protein immunogen to elicit M type cross-reactivity

The paper designs an M protein immunogen that elicits cross-reactivity against multiple M types by targeting a conserved 3D pattern in the hypervariable region.

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

This study identifies shared cellular and molecular features between severe COVID-19 and idiopathic pulmonary fibrosis, highlighting ER stress and AT2 cell dysfunction as key drivers.