Author

E. V. Ledger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Organism:E. coli· 1 Organism:human· 1

Frequent Co-Authors

A. M. Edwards· 3 shared A. Edwards· 1 shared A. R. Tickle· 1 shared C. J. Pee· 1 shared E. W. Tate· 1 shared K. Lau· 1 shared S. Mesnage· 1 shared V. Pader· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 8 mutual co-author links

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3 shared papersMicrobiology

A. M. Edwards

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human serum induces daptomycin tolerance in Enterococcus faecalis and viridans group streptococci

A. R. Tickle, E. V. Ledger, A. M. Edwards

This study shows human serum induces daptomycin tolerance in Enterococcus faecalis and viridans group streptococci, which can be mitigated by fosfomycin or combination therapy.

bioRxiv · Oct 12, 2022 · PreprintMicrobiology

XerC is required for the repair of antibiotic- and immune-mediated DNA damage in Staphylococcus aureus

E. V. Ledger, K. Lau, E. W. Tate, A. M. Edwards

This study identifies XerC as essential for DNA repair in Staphylococcus aureus, increasing susceptibility to antibiotics and immune defenses.

bioRxiv · Sep 4, 2022Microbiology

Human serum triggers antibiotic tolerance in Staphylococcus aureus

E. V. Ledger, S. Mesnage, A. M. Edwards

This study shows human serum induces antibiotic tolerance in MRSA through two mechanisms involving cell wall changes and membrane composition, suggesting fosfomycin could enhance daptomycin efficacy.

bioRxiv · Nov 11, 2021Microbiology

A FASII inhibitor prevents staphylococcal evasion of daptomycin by inhibiting phospholipid decoy production

C. J. Pee, V. Pader, E. V. Ledger, A. Edwards

This study shows that an FASII inhibitor enhances daptomycin's effectiveness against S. aureus by blocking phospholipid decoy production, which inactivates the antibiotic.

bioRxiv · Sep 27, 2018Microbiology