A. Edwards

Co-Activation Patterns Characterize Early Resting-State Networks in Newborn Infants: A High-Density Diffuse Optical Tomography Study

This study applies co-activation pattern analysis to neonatal HD-DOT data to identify dynamic functional connectivity features in newborns.

CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.

The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.

HR3/RORα-mediated cholesterol sensing regulates TOR signaling

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

A frosty genetic screen unmasks a major regulatory role for SHORT VEGETATIVE PHASE of flowering in response to a cold snap

The paper identifies SVP gene mutations that delay flowering in Arabidopsis during cold snaps, revealing SVP's role in repressing FT expression.

Cyclone: an accessible pipeline to analyze, evaluate and optimize multiparametric cytometry data

Cyclone is a pipeline for analyzing, evaluating, and optimizing multiparametric cytometry data, demonstrating effectiveness across multiple cytometry technologies and biological contexts.

Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology

The paper designs transmembrane proteins that inhibit the erythropoietin receptor by competing with homodimerization in a custom binding topology.

Linear versus Nonlinear Muscle Networks: A Case Study to Decode Hidden Synergistic Patterns During Dynamic Lower-limb Tasks

This paper compares linear and nonlinear muscle networks during dynamic lower-limb tasks, finding that nonlinear networks better capture synergistic patterns in complex tasks like sit-to-stand.

Trajectory classification method for anchored molecular motor-biopolymer interactions in the C. elegans first mitosis.

The paper presents a method to classify cortical force generating units in C. elegans mitosis using single molecule imaging and dynein trajectory analysis, revealing microtubule interactions and force asymmetries.

The identification of potent and selective antibodies for Serine/threonine-protein kinase TBK1, for use in immunoblot, immunofluorescence and immunoprecipitation

The paper evaluates 11 commercial antibodies for TBK1 detection in immunoblot, immunofluorescence, and immunoprecipitation using a knock-out cell line to identify potent and selective antibodies.

Prolonged β-Adrenergic Stimulation Disperses Ryanodine Receptor Clusters in Cardiomyocytes: Implications for Heart Failure

This study shows prolonged β-adrenergic stimulation causes RyR cluster dispersion in cardiomyocytes, disrupting Ca2+ homeostasis and contributing to heart failure.

Stabilizing selection shapes variation in phenotypic plasticity

The paper tests stabilizing selection on phenotypic plasticity in Daphnia pulex by analyzing genetic variation in anti-predator defenses under predation risk.

Active Surveillance Characterizes Human Intratumoral T Cell Exhaustion

The paper studies T cell exhaustion in human tumors using live-biopsy and two-photon microscopy, finding variable T cell speed and a link between motility and exhaustion state.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

In Vitro Safety "Clinical Trial" of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy

This paper uses a cardiac microphysiological system to assess the cardiotoxicity of hydroxychloroquine and azithromycin polytherapy, finding increased QT interval and reduced arrhythmias compared to monotherapy.

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

This study improves electrophysiological maturation of hiPSC-derived cardiomyocytes by combining metabolic cues and biophysical stimuli, revealing genotype-dependent responses to maturation media.

Unlinked rRNA genes are widespread among Bacteria and Archaea

The paper shows that unlinked 16S and 23S rRNA genes are common in many bacterial and archaeal phyla, not just rare exceptions, and are associated with specific ecological and metabolic traits.

Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence

This paper identifies a phase-variable signal transduction system in C. difficile that controls colony morphology, motility, and virulence, with implications for bacterial survival and pathogenesis.

Scientific societies advancing STEM workforce diversity: Lessons and Outcomes from the Minorities Affairs Committee of the American Society for Cell Biology

The paper discusses the role of scientific societies in advancing STEM workforce diversity through programs and mentoring, highlighting outcomes from the American Society for Cell Biology's Minorities Affairs Committee.

89Zr-oxine labelling and PET imaging shows lung delivery of a cell/gene cancer therapy

The paper demonstrates that 89Zr-oxine PET imaging can track MSCTRAIL cell therapy biodistribution in a lung cancer mouse model, showing lung delivery and viability.

Differential remodeling of the electron transport chain is required to support TLR3 and TLR4 signaling and cytokine production in macrophages

The paper shows that TLR3 and TLR4 signaling in macrophages involves differential remodeling of the electron transport chain, which affects ROS production and cytokine responses.

Illuminating the functional rare biosphere of the Greenland Ice Sheet’s Dark Zone

The paper analyzes microbial communities in the Greenland Ice Sheet’s Dark Zone using 16S rRNA gene and cDNA data to reveal the role of rare taxa in albedo reduction and melting.

A global perspective on microbial diversity in the terrestrial deep subsurface

This study analyzes microbial diversity in the terrestrial deep subsurface using 16S rRNA gene data, finding that aquifer lithology controls bacterial community diversity and identifying a core microbial consortium across different rock types.

Characterization of the interactive effects of labile and recalcitrant organic matter on microbial growth and metabolism

The paper tests how different organic matter pools affect marine bacteria growth and respiration, finding species-specific and transient interactive effects.

Centrosome-nuclear envelope tethering and microtubule motor-based pulling forces collaborate in centrosome positioning during mitotic entry

The paper investigates how PP2A-B55/SUR-6 and nuclear lamina regulate centrosome positioning through nuclear size and Dynein density during mitotic entry.

A FASII inhibitor prevents staphylococcal evasion of daptomycin by inhibiting phospholipid decoy production

This study shows that an FASII inhibitor enhances daptomycin's effectiveness against S. aureus by blocking phospholipid decoy production, which inactivates the antibiotic.

Mixing is required for uniform reconstitution of filter-dried protein antigens in a single-injection vaccine formulation

This study shows that mixing improves the uniformity and release of filter-dried protein antigens in a single-injection vaccine formulation.