Author

S. Mesnage

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

T. K. Prajsnar· 2 shared A. E. Acosta-Martin· 1 shared A. Hounslow· 1 shared A. M. Edwards· 1 shared A. M. Guzman Prieto· 1 shared A. Nichols· 1 shared A. Patel· 1 shared A. Rifflet· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersMicrobiology

T. K. Prajsnar

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6 papers

Recent·Most cited

Unusual 1-3 peptidoglycan cross-links in Acetobacteriaceae are made by L,D-transpeptidases with a catalytic domain distantly related to YkuD domains

S. MESNAGE, M. G. Alaman-Zarate, B. J. Rady, C. A. Evans, B. Pian, D. Greetham, S. Marecos-Ortiz, M. J. Dickman, I. D. Lidbury, B. Barstow

The paper identifies 1-3 peptidoglycan cross-links in Gluconobacter oxydans using modified PGFinder software and discovers an L,D-transpeptidase with a YkuD-related domain responsible for these cross-links.

bioRxiv · Oct 31, 2023Microbiology

Human serum triggers antibiotic tolerance in Staphylococcus aureus

E. V. Ledger, S. Mesnage, A. M. Edwards

This study shows human serum induces antibiotic tolerance in MRSA through two mechanisms involving cell wall changes and membrane composition, suggesting fosfomycin could enhance daptomycin efficacy.

bioRxiv · Nov 11, 2021Microbiology

PGfinder, a novel analysis pipeline for the consistent, reproducible and high- resolution structural analysis of bacterial peptidoglycans

A. V. Patel, R. D. Turner, A. Rifflet, A. E. Acosta-Martin, A. Nichols, M. M. Awad, D. Lyras, I. Gomperts Boneca, M. Bern, M. Collins, S. Mesnage

PGfinder provides an automated pipeline for high-resolution structural analysis of bacterial peptidoglycans, enabling consistent and reproducible quantification of PG fragments and discovery of novel structural features.

bioRxiv · Jun 1, 2021Microbiology

A Superfamily of T6SS Antibacterial Effectors Displaying L,D-carboxypeptidase Activity Towards Peptidoglycan

S. Sibinelli-Sousa, J. T. Hespanhol, G. G. Nicastro, B. Y. Matsuyama, S. Mesnage, A. Patel, R. F. de Souza, C. R. Guzzo, E. Bayer-Santos

The paper identifies Tae5STM as a T6SS effector with L,D-carboxypeptidase activity that cleaves peptidoglycan, revealing a new superfamily of bacterial effectors involved in interbacterial competition.

bioRxiv · Feb 18, 2020Microbiology

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and resistance to innate immunity

R. E. Smith, B. Salamaga, P. Szkuta, N. H. Hajdamowicz, T. K. Prajsnar, G. Bulmer, T. Fontaine, J. Kołodziejczyk, J.-M. Herry, A. Hounslow, M. P. Williamson, P. Serror, S. Mesnage

This study identifies the role of EPA decoration in E. faecalis virulence, cell surface charge, and resistance to innate immunity.

bioRxiv · Dec 6, 2018Microbiology

Fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum

X. Zhang, A. M. Guzman Prieto, V. de Maat, T. K. Prajsnar, J. R. Bayjanov, M. de Been, M. R. C. Rogers, M. J. M. Bonten, S. Mesnage, R. J. L. Willems, W. van Schaik

This study identifies genes essential for vancomycin-resistant Enterococcus faecium growth in human serum and their role in virulence.

bioRxiv · Jan 21, 2017Microbiology