PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle
M. Benzarti, A. Oudin, E. Viry, E. Gargiulo, M. Schmoetten, L. Neises, C. Pulido, N. I. Lorenz, M. W. Ronellenfitsch, D. Sumpton, M. Warmoes, C. Jaeger, A. Lesur, J. Paggetti, E. Moussay, , J. Meiser
This study reveals that PKM2 inhibition redirects glycolytic and glutamine carbons into distinct metabolic pathways, supporting cancer cell metabolic flexibility under glycolytic limitation.
bioRxiv · Jan 23, 2023Cancer Biology