D. Sumpton

Uridine Phosphorylase-1 supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes of the lung

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis

This study shows that triple-negative breast cancer cells secrete anti-ferroptotic MUFAs and rely on selenoprotein synthesis for metastasis.

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

This study uses metabolomics to stratify colorectal cancer tissues and identifies adenosylhomocysteinase as a potential therapeutic target.

PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

This study reveals that PKM2 inhibition redirects glycolytic and glutamine carbons into distinct metabolic pathways, supporting cancer cell metabolic flexibility under glycolytic limitation.

Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing

The paper shows that inhibiting mitochondrial folate metabolism drives differentiation in CML cells via mTORC1 and purine sensing, and enhances the efficacy of imatinib in reducing therapy-resistant LSCs.

THEM6-mediated lipid remodelling sustains stress resistance in cancer

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

Cyclocreatine suppresses prostate tumorigenesis through dual effects on SAM and creatine metabolism

This study identifies cyclocreatine as a dual-action inhibitor of prostate cancer by blocking the phosphagen system and increasing S-adenosyl methionine levels.

Schlafen family member 5 (SLFN5) regulates LAT1-mediated mTOR activation in castration-resistant prostate cancer

This study identifies SLFN5 as an AR-regulated biomarker in CRPC that promotes tumour growth by regulating LAT1-mediated mTOR activation.

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

Impact of formate supplementation on body weight and plasma amino acids

This study examines the effects of sodium formate supplementation on body weight, plasma amino acids, and gut microbiota in mice, finding significant changes in females but not males.

Formate induces a metabolic switch in nucleotide and energy metabolism

This study shows formate induces a metabolic switch increasing adenine nucleotides, glycolysis, and repressing AMPK, with implications for cancer metabolism.