C. Jaeger

Formate Promotes Invasion and Metastasis by Activating Fatty Acid Synthesis and Matrix Metalloproteinases

PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

This study reveals that PKM2 inhibition redirects glycolytic and glutamine carbons into distinct metabolic pathways, supporting cancer cell metabolic flexibility under glycolytic limitation.

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

This study identifies mitochondrial one-carbon metabolism as a key driver of cancer cell migration and metastasis independent of proliferation.

Abundance, fatty acid composition and saturation index of neutral lipids are significantly different between isogenic primary and metastatic colon cancer cell lines

This study compares lipid composition between primary and metastatic colon cancer cell lines, finding significant differences in triglyceride and cholesterol ester saturation indices.

Cancer cell lipid class homeostasis is altered under nutrient-deprivation but stable under hypoxia

The paper examines how cancer cells adjust lipid homeostasis under nutrient-deprivation and hypoxia, finding that lipid class stability is maintained under hypoxia but disrupted under nutrient-deprivation.