Lysosomal uptake of mtDNA mitigates heteroplasmy
P. Kakanj, M. Bonse, A. Gokmen, F. Gaedke, B. Molla, E. Vogelsang, A. Schauss, A. Wodarz, D. Pla-Martin
The paper shows that lysosomal uptake of mtDNA reduces heteroplasmy by enhancing mtDNA turnover through retromer-mediated mechanisms in Drosophila.
bioRxiv · Feb 16, 2024 · PreprintCell Biology