Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma
R. Russell, M. Akuma, M. Kim, C. Zhu, E. Wiljer, A. Gaudreau-Lapierre, L. Patterson, L. Trinkle-Mulcahy, W. L. Stanford, Y. Riazalhosseini
This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.
bioRxiv · Apr 14, 2024Cancer Biology