M. Kim

Loss of adenylosuccinate synthetase 1 in mice recapitulates features of ADSS1 myopathy

This paper presents a mouse model of ADSS1 myopathy by knocking out Adss1 and characterizes its motor deficits and histopathological features.

New insights into the role of oxytocin signaling in preeclampsia

This study investigates oxytocin signaling's role in preeclampsia by analyzing placental and plasma samples, revealing its association with placental dysfunction and potential as an early diagnostic biomarker.

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

Mitochondria affect photosynthesis through altered tissue levels of oxygen

The paper investigates how mitochondrial function affects photosynthesis by altering tissue oxygen levels in Arabidopsis, showing that increased mitochondrial oxygen consumption reduces chloroplast oxygen availability.

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

Proteostasis Landscapes of Cystic Fibrosis Variants Reveals Drug Response Vulnerability

The paper uses proteomics and computational modeling to analyze CFTR variants, identifying structural vulnerabilities in NBD1 that limit corrector efficacy and suggesting secondary mutations as a therapeutic strategy.

Clostridioides difficile binary toxin CDT induces biofilm-like persisting microcolonies

This study shows that CDT toxin from Clostridioides difficile induces biofilm-like microcolonies, increasing colonization and persistence in intestinal models and infected mice.

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-Cholangiocarcinoma

This study contrasts the effects of developmental and acute Sox9 deletion in cHCC-CCA models, showing that Sox9 elimination can reduce tumor burden and highlights therapeutic potential.

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice

This study shows that transferring gut microbiota from young and estropausal mice improves ovarian function and fertility in adult mice.

Mathematical model of intestinal lipolysis of a long-chain triglyceride

This paper develops a kinetic model to predict triglyceride digestion in the intestine, showing it aligns with experimental data and outperforms simpler models.

Distraction Impact of Concurrent Conversation on Event-Related Potential Based Brain-Computer Interfaces

This study examines how concurrent conversation affects ERP-based BCIs, finding that speaking degrades accuracy and ERP amplitude while listening has less impact.

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.

Assessing Long-Term Stored Tissues for Multi-Omics Data Quality and Proteogenomics Suitability

This study evaluates the quality and suitability of long-term stored tissues for multi-omics analyses, showing that while transcriptomic data show some changes, core gene expression and proteomic measurements remain reliable.

Risk assessment predicts most of the salmonellosis risk in raw chicken parts is concentrated in those few products with high-levels of high-virulent serotypes of Salmonella

The paper assesses salmonellosis risk in raw chicken parts using microbial risk assessment, finding most illnesses are attributed to a small fraction of products with high levels of high-virulent Salmonella serotypes.

High-Resolution Spatial Transcriptomic Atlas of Mouse Soleus Muscle: Unveiling Single Cell and Subcellular Heterogeneity in Health and Denervation

In-situ microscopy-assisted meniscus-guided coating for highly sensitive reduced graphene oxide-based nanocomposite biosensor

The paper develops a meniscus-guided coating technique using in-situ microscopy and CFD modeling to create high-performance rGO-based biosensors with picomolar detection limits.

Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration

This paper presents a 3D-printed composite scaffold system for bone regeneration that accelerates ECM and mineralized osteoid deposition in vivo.

Circadian rhythms of macrophages are altered by the acidic pH of the tumor microenvironment

This study shows that the tumor microenvironment alters macrophage circadian rhythms, affecting tumorigenesis and macrophage function.

Phototropin connects blue light perception to starch metabolism in green algae

The paper identifies a blue light signaling pathway in green algae that inhibits starch accumulation via PMSK1 dephosphorylation and GAP1 repression.

DYRKP kinase regulates cell wall degradation in Chlamydomonas by inducing matrix metalloproteinase expression

This study identifies DYRKP kinase as a regulator of cell wall degradation in Chlamydomonas by inducing MMP expression, enabling daughter cell hatching.

Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling

This study shows that IPMK regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling, impacting immune responses and autoimmune disease models.

Revealing 3D cancer tissue structures using holotomography and virtual hematoxylin and eosin staining via deep learning

This paper develops a 3D virtual H&E staining method using holotomography and deep learning for cancer tissues, validated on colon and gastric cancer samples.

Identification and Analysis of SARS-CoV-2 Mutation and Subtype using 2x tiled Primer Set with Oxford Nanopore Technologies Sequencing for Enhanced Variant Detection and Surveillance in Seoul, Korea

The paper uses long-read sequencing with a 2x tiled primer set to identify SARS-CoV-2 mutations and subtypes in Seoul, Korea, showing improved variant detection and genotype-patient characteristic correlation.

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

Translation as a Biosignature

This paper proposes that translation apparatuses, like ribosomes, could serve as biosignatures for detecting extant life beyond Earth and demonstrates machine learning's ability to classify biomolecules.

Sensitivity analysis of models of gas exchange for lung hyperpolarised 129-Xe MRS and MRI.

The paper performs a sensitivity analysis on 129-Xe gas exchange models to identify influential parameters and optimize model composition for lung function and microstructure assessment.

Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin

This study shows early-life thermal stress increases TSP-1 in C. elegans, leading to longevity and resilience through tetraspanin web formation.

Independent component analysis (ICA) applied to dynamic oxygen-enhanced MRI (OE-MRI) for robust functional lung imaging at 3 T

This paper applies independent component analysis to dynamic oxygen-enhanced MRI to extract oxygen-induced signals and assess lung function differences between smokers and non-smokers.

XPA tumor variants lead to defects in NER that sensitize cells to cisplatin

This study identifies XPA tumor variants that impair NER, increasing cisplatin sensitivity, and provides mechanistic insights for variant effect prediction.

Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

The paper shows that HIV-1 MPER-targeting antibodies generated by vaccines lack structural constraints needed to access the MPER, despite having bnAb-like paratopes.