C. Zhu

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

This study shows NCOR1 regulates Treg cell differentiation and suppressive function by maintaining transcriptional integrity in both naive and effector states.

Mechanical force regulates ligand binding and function of PD-1

This study shows mechanical force is critical for PD-1 function, as soluble PD-L1 lacks the mechanical support needed to trigger PD-1 signaling.

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.

Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

This study tracks microbiome changes across four body sites in 86 participants over six years, revealing site-specific stability, individualized dynamics, and altered patterns in insulin-resistant individuals.

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

Evolutionary fingerprints of EMT in pancreatic cancers

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes

The paper shows IgA1 autoantibodies enhance pDC IFN responses when combined with IgG in RNA-containing immune complexes through FcR receptor interaction.

Computational exploration of the global microbiome for antibiotic discovery

The paper uses machine learning to predict antimicrobial peptides from microbiome data, identifies novel peptides, and validates their antibacterial activity against drug-resistant pathogens.

Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome

This study shows that CD40-CD40L interactions form catch bonds that enhance B cell signaling and antibody class-switch, and mutations in CD40L disrupt this mechanism, causing X-linked Hyper IgM syndrome.

Serpine1 negatively regulates Th1 cell responses in experimental autoimmune encephalomyelitis.

This study shows Serpine1 inhibits Th1 cell pathogenicity in EAE by promoting Tim-3 expression and function.

Structural insights into dual-antagonize mechanism of AB928 on adenosine A2 receptors

This study determines the crystal structures of A2AR with AB928 and 2-118, revealing distinct binding modes on A2AR and A2BR that explain AB928's dual-antagonistic properties.

Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

Cholangiocytic differentiation drives cell proliferation in hepatoblastoma through Wnt-dependent FGF19 signaling

The paper identifies FGF19 as a paracrine signal driving tumor growth in hepatoblastoma through Wnt-dependent mechanisms and biliary lineage activation.

Targeting the catalytic activity of HDAC1 in T cells protects against experimental autoimmune encephalomyelitis

This study shows that inhibiting HDAC1 catalytic activity in T cells prevents experimental autoimmune encephalomyelitis by reducing proinflammatory cytokines and effector functions.

Force-regulated spontaneous conformational changes of integrins α5β1 and αVβ3

This study compares force-induced conformational changes in integrin ectodomains α5β1 and αVβ3, revealing distinct mechanical behaviors and energy landscapes.

Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

Memory in Repetitive Protein-Protein Interaction Series -- in Memory of the Late Professor Robert M. Nerem

The paper analyzes memory effects in repetitive protein-protein interactions using experimental techniques and models, finding short- and intermediate-term memory in TCR-pMHC interactions.

Tumor microenvironments impair T cell receptor affinity and function

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling

This study identifies Rin-like as a negative regulator of Tfh differentiation in mice and humans, showing its role in CD28 signaling and endocytosis.

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

This study shows that MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer by affecting chromatin modifications and gene expression.

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.

Spatiotemporal heterogeneity and the long-term impact of meteorological , environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

RNA Methylome Reveals the m6A-Mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-Withering

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

Parallel lipid-carried epitope pillars enhance stimulation of chimeric antigen receptor T cells

This study shows that glycosylphosphatidylinositol-anchored MUC1 epitope pillars enhance chimeric antigen receptor T cell stimulation, with tandem repeat sequences showing greater activity.

Cooperative cis-interactions between ectodomains of TCRαβ CD3 subunits enable mechanotransduction

The paper quantifies cooperative cis-interactions between TCRβ and CD3 subunits, showing they form catch bonds that mechanically regulate TCR signaling.

A multiplexed in vivo approach to identify driver genes in small cell lung cancer

The paper develops a multiplexed in vivo approach to identify driver genes in SCLC using CRISPR/Cas9 and lentiviral barcoding, finding TSC1 as a robust tumor suppressor.

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.