Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis
A. Slonchak, X. Wang, H. Chaggar, J. Aguado, M. Freney, K. Yan, F. J. Torres, A. A. Amarilla, R. Balea, J. D. J. Sng, Y. X. Setoh, N. Peng, D. Watterson, E. Wolvetang, A. Suhrbier, A. A. Khromykh
This study identifies how ZIKV sfRNA interacts with NS5 to inhibit STAT1 phosphorylation, promoting viral pathogenesis in placental and neural tissues.
bioRxiv · May 18, 2021Microbiology